Cytokine Dump and Osteoarthritis ?

[mtrafter]

Followed with interest the thread on Cytokine storm and our PMR cytokine dump and wondered if it occurs in OA. I am woken most early mornings around 2 to 3am with severe pain in my arthritic knees . Decided 3 days ago to add an extra 1 mg of Pred as an evening dose to the 5mg I take in the morning and voila no nocturnal pain! Less stiffness in morning and no back pain. The question is

-Can OA also have a cytokine dump

-Have I been on too low a dose? tapered to 5 mg 3 wks ago( using a 5mth taper )after been stuck on 6.5 for 18mths.

- The lower Pred dose has allowed my arthritis to emerge more fully

Would love to hear of others experience of PMR and OA.

[jinasc]

Have you tried this for your Osteo - Flexiseq (a bio logical cream) developed by ARC and a German Pharma. Works like WD40 - used it for over 4 years. It is expensive but it can be bought on the big A. One tube is well worth a try. Make sure you follow the instructions.

[mtrafter in reply to jinasc]

Thanks for your suggestion I will check it out. My usual routine to manage my OA is panadol osteo ii morning and night , and application of Voltaren (Diclofenac diethylamine 23.2mg ) cream at same time, this helps to a manageable degree except for the early morning!

[jinasc in reply to mtrafter]

You use it twice a day - every 12 hours, so I put it on before I go to bed and then see what it is like on waking up and then apply if in pain. No pain then either wait till the pain starts or the 12 hours are up. I refuse to be in pain. When ARC announced it...............I pounced on it. The attraction, bio-mechanical and I did not want to use tablets.

BTW the osteo in my fingers it great, we found this out as you sit for ten minutes to let the gel disappear. Another Lady who used it and had not been able to knit for over 10 years, guess what she is knitting again.

[mtrafter in reply to jinasc]

I'm willing to try anything to reduce the pain and number of oral meds I take. Have looked into Flexiseq seems might be a bit hard to get in Aust.

[PMRpro Ambassador]

Some Chinese work found that there is involvement of cytokines in OA - including IL-6 which is what is involved in PMR.

And this

ncbi.nlm.nih.gov/pmc/articl...

is a better and easier read for the introduction and conclusion at least.

"This study showed that serum levels of IL-6 and IL-10 were higher in knee OA than in healthy controls. A positive association between IL-10 and IL-6 with VAS and WOMAC for pain and rigidity scores was found. These findings align with a physiopathological understanding of pain and functionality that surpasses the one which currently provides basis for therapeutics in OA."

[mtrafter in reply to PMRpro]

Thanks so much for this information it looks like a heavyread for this time of night. I'll get into in the morning when my brain is working😉

[PMRpro Ambassador in reply to mtrafter]

You really only need the intro and the conclusion!!!