I take 18.5 mg of prednisone in the morning and 17.5 mg amitriptyline at bedtime. I've noticed a pattern-- I'm short-tempered, get hot flashes, and extremely jittery by 5:00 in the evening. Sometimes I'm overly tired. This isn't the case all the time though, and it really bothers me. I'm wondering if I should reduce/increase the amitriptyline. Perhaps this is still prednisone doing a job on my mental processes.