hereditory

[pollyg263]

i did not know pmr was hereditory i have had pmr for 7 years, back down to 1 mg. but my daughter who lives in brisbane spoke to me and said she had been to her doc with leg pain. and he said has anyone in the family had pmr.

anyone know the answer x

[scats]

It is widely believed that there is a genetic componant but environment and stress are also involved. There is definitely a genetic link in my family. My father had it and now my brother, sister and myself. My sister's case is non-typical and was diagnosed because of me and her brother having PMR.

[CT-5012]

Oh yes, I have PMR and GCA my brother has GCA and all our children have some form of autoimmune disease. B*#£@y Vikings!

[scats in reply to CT-5012]

I see I shall have to report you to the Godess Freya!

[DorsetLady PMRGCAuk volunteer]

In response to CT-5012 reply see this post (slightly tongue in cheek, but with some evidence of why we may get GCA and/or PMR)-

healthunlocked.com/pmrgcauk...

[Yellowbluebell in reply to DorsetLady]

Loki? Now that's a thought. Might explain a few things that happen on here!!

[DorsetLady PMRGCAuk volunteer in reply to Yellowbluebell]

did name someone that!

[SheffieldJane]

Some of us do have relatives who have had PMR or even the same sort of symptoms but never named as PMR. The predisposition to Autoimmune diseases may well be inherited. PMR also strikes Northern people , particularly with a Scandinavian background. So there must be an inherited factor at play. ( Vikings).

[CT-5012 in reply to SheffieldJane]

Vikings again 🤬

[Rimmy]

Said to 'aggregate in families' the genetic link is there - me with PMR&GCA and my mother (with 'only' GCA) so far although she was never officially diagnosed. That in itself is a factor of course - my Mum had what was now retrospectively & obviously GCA in the early 1970's and the docs she saw had absolutely no idea then - even suggesting she had a brain tumour and doing a fruitless (I think 'reckless') operation after which she started to have seizures. She was never prescribed Pred - lost eyesight and had sequential 'small' strokes. Many of her generation (born around the 1920s) probably completely slipped under the radar and so as a 'Mid-Century' babies hard to say for sure about parents or other predecessors. Now these genetic links might become more apparent as the medical profession becomes better informed. Still not nice to have to 'warn' any kids to keep an 'eye out' when they are 'older'.

[DorsetLady PMRGCAuk volunteer in reply to Rimmy]

We parents get blamed by our kids for everything - so one more added to the list is immaterial! 🙈

[Rimmy in reply to DorsetLady]

Too true DL !! X

[cranberryt]

I ave read there is a genetic marker that has a higher association with PMR. My aunt was just dx with it as well. So I do believe there can be a genetic susceptibility to it.

[Grants148]

My mother had PMR,but not until she had reached her nineties,l was in my seventies when diagnosed .l hope my sons do not get it !

[PMRpro Ambassador]

PMR is NOT hereditary - there is a genetic component to it but that just means that you are more likely to develop it. And of course your parents/grandparents/other family have a similar genetic heritage.

[Purplecrow in reply to PMRpro]

With all due respect...Question Please, the terms "genetic component and hereditary" seem related...certainly there is a difference, but splitting hairs comes to mind.

My entire family has some variety of auto-immune disorders, eg. Lupus, PMR, etc. We are Native American plus European.

💜🙏🏽

[PMRpro Ambassador in reply to Purplecrow]

Hereditary means it is associated with a specific gene or genes - such as cystic fibrosis, some breast cancers or muscular dystrophies. In the case of PMR/GCA they have not identified such a pattern but it is known that people with a Scandinavian heritage are more likely to have a predisposition to PMR/GCA.

It may sound like semantics but there is a difference.

[whitefishbay in reply to Purplecrow]

Great name Purplecrow.

[Purplecrow in reply to whitefishbay]

😊

[Purplecrow]

I see the point, thanks.

💃🏼

[Pmrmolly2018]

Me, my sister who is 7 years younger and two first line cousins all diagnosed within a 12 month period! My daughter at 51 now fibromyalgia, another auto immune disease. We definitely have Northern European origins as DNA tests show.

[Suet3942]

My mother and her sister had gca and pmr. Their mother was bed bound with pain so probably had undiagnosed pmr. My cousin on my dad's side also has gca and pmr so I've got a double whammy!

[Purple-Owl]

My mother lost her eyesight with GCA. I have PMR.

[Marcy47]

My mother had PMR in her 70's, she was born in 1914. I started with it at 68. My 2 sisters are OK, also my 2 daughters so far, aged 50 and 47.

[Spanky2019]

I have gca. My mom had pmr. I'm not an expert but that's how it is in my family.