Been on pred for a fortnight now. My crp was 28 before I started pred (although it has been over 50 in the past). Rheumatologist put me on 15 mg but I still felt bad after a week so increased it to 17.5. After a week at that dose my crp is 15. So things are moving in the right direction but should I up the dose to 20 to try and get crp normal? Rheumatologist just said 15 for a fortnight then reduce to 12.5 for a fortnight. But in answer to my last post on this forum it was suggested that guidelines state you can start on more than 15. Don't know what rheumatologist bases initial dose on. Seems a bit random to me. Also hard to contact him for advice. They aren't very accessible!