AMA Question

[Jenni4962]

Hi everyone, I was just dismissed from my hepatologist because I have positive AMAs and have had them for 4 years now but with normal lfts and also had a biopsy that came back normal. My AMAs drawn 4 years ago was 1:70 and now they are 1:45. I know there a a few others like me on here with only AMAs and no PBC (as of yet) my question is, is my titre considered low and what are my chances I will ever get PBC. Does anyone else know their AMA titre? I was reading most people with PBS have one 160 or higher. Im still so worried! If anyone can answer me that would be great, you are all such a great help.

[gwillistexas]

When I was diagnosed June 2017 my ANA titer was 1:640. Should be less than 1:40. My lab was sent to Austin.

[Jenni4962 in reply to gwillistexas]

Thanks for the reply. I know Im still positive just wasnt sure why it went down from 70 to 45. I was never tested for ANA just AMA.

[gwillistexas in reply to Jenni4962]

I didn’t know AMA had a titer. That’s why I posted ANA Titer😊 my Mitochondrial M2 AB was 128.0. Should be less than 20.0

[Jenni4962 in reply to gwillistexas]

Oh ok thanks! Yes thats what they told me, that it should be less than 20 and im 45 so still positive even though it dropped

[HealthyChik in reply to gwillistexas]

My ANA was 1:1280😱

[HealthyChik]

My AMA-M2 was 104. I was diagnosed last July and haven't had it checked since.

[HealthyChik in reply to HealthyChik]

And try not to worry. I'm sure your primary doc will routinely monitor your liver enzymes, etc. and if not...ask them to keep a check on it. It will ease your mind and you may NEVER develop PBC. So in the mean time do a happy dance and enjoy life. Congrats on getting dismissed from the hepatologist💕

[Jenni4962 in reply to HealthyChik]

Thank you for responding! And yes, my dr will monitor my LFTs yearly.

[Michi1]

AMA can indicate conditions other than PBC. Did you ever have elevated LFTs? Maybe you don't have PBC, and never did.

[Jenni4962 in reply to Michi1]

No, never had any other elevated LFTs, except slightly bilirubin but my dr said thats due to a benign condition called Gilberts Syndrome. That means my bilirubin will sometimes be slightly elevated on some blood draws, sometimes normal. Biopsy was negative

[Michi1 in reply to Jenni4962]

Elevated ALT, AST, and ALP, in a certain pattern, are necessary for a PBC diagnosis.

[gwillistexas in reply to Michi1]

AMA M2 is suggestive of PBC. I believe there are 9 codes for AMA.