I've had PBC for about 5 or 6 years now. Touch wood I have been ok. No itching and def no tiredness, in fact just the opposite, I hardly sleep at all. 3-4 hours a night is normal with the exception of 1 early night now and again ! I take 500mg of Urso daily. My specialist was very pleased on my recent visit, saying whatever I'm doing , too keep it up. I do stay clear of too much fatty food and alcohol. But what I do take about 3 times a day is a teaspoon of Organic Apple Cider Vinegar in a glass of water. Does anyone else have this ? If so do you think it has improved the health of your liver.