I have not been diagnosed yet, but my Dr thinks I may have it. I started itching on my hands and feet so bad I wanted to sand the off then I got very sick for a few weeks and my liver count was alert high AST 1400 and ALT 2300 and I had yellow skin and eyes, gray stool, very nauseous, & extremely fatigued. I felt better after a few weeks and had my blood tested again. My AST is now 87 and ALT went down to 162 but my M2 antibodies is at 50.2 and should be 0-20. I am feeling better no yellow, stool back to normal, nauseous sometimes and fatigue only when I go to work. The itching has stopped. But my dr wants to have a liver biopsy because of the M2 antibodies being high. Does this sound familiar to any one? It sounds like PBC but I don't know why I am starting to feel better and my liver test enzymes and going down. Please if anyone has any input I would love to here it.