PBC v PSC: Hi can any one tell me the... - PBC Foundation

PBC Foundation

9,476 members8,330 posts

PBC v PSC

Kieraferret profile image
6 Replies

Hi can any one tell me the difference between p b c and p s c as far as I can tell they both attack the bile duct .

Written by
Kieraferret profile image
Kieraferret
To view profiles and participate in discussions please or .
6 Replies

Hello Kieraferret.

Well that got me wondering too quite some time ago too. I think for a start there has to be different factors. In PBC for eg majority of us are found to have a positive for the antibodies - anti-mitochondrial (AMAs). Not sure what is present in PSC.

In PSC though it seems that the bile ducts inflame and can be prone to become blocked whereas in PBC the bile ducts that are under attack seem to start disappearing.

I think symptons of fatigue and itching seem common as they do in liver conditions. Seems that it is a more 'man thing' to have PSC whereas PBC seems more a 'woman thing' (excuse the terminology).

I think like PBC too, PSC can lead to cirrhosis eventually if that is how it progresses.

The PBC is what I have. Yes it has to do with the Bile Duct.. But the Bile does not go thru the Liver to clean out all the bad stuff...

Jojowen profile image
Jojowen

Hi, as far as I have understood it PSC attacks the somewhat bigger biletree "veins" in the liver, wheras PBC destroys the smaller ones. But when I write this I suddenly realise I really have no idea... PSC seems to be worse though, more aggressive and more often leading to liver cancer. Next week I am starting an on line liver course. Might know more soon. Interesting question!

J

Kieraferret profile image
Kieraferret in reply toJojowen

Thanks

NotorDJP profile image
NotorDJP

PSC attacks the primary, large bile duct whereas PBC attacks the smaller bile duct. Men usually get PSC and usually have Ulcerative colitis as well. Women mainly get PBC. PSC usually has a more severe prognosis, though they give Urso to both patients. PSC is known to not respond to Urso as well as PBC and since is the main Bile Duct, damage is usually more severe more quickly. That is the extent of my knowledge!

Kieraferret profile image
Kieraferret

Thank you

Not what you're looking for?

You may also like...

Pbc with psc overlap

Hi can anyone help me , I was diagnosed with Pbc in 2012 and have been on urso since then , but my...
Kieraferret profile image

PBC and PSC

Have any of you also been diagnosed with PSC? I know it is extremely rare to have PBC and PSC, but...
amanda3296 profile image

PBC or PSC ?

After 9 years of being told I have PBC I visited the consultant today and he says hes not sure that...
jennyspringer profile image

PSC....?

I have been having tests since Jan of this year. I have neg AMA, ANA and SMA. I have had a liver...

fibro v pbc

hi all i have had pbc 8 yrs urso 1000mgfor last 3 was diagnosed fibro 2 yr back how am isupposed to...

Moderation team

See all
PBCCheryll profile image
PBCCheryllAdministrator
janethomas profile image
janethomasModerator
Cupcake1971_ profile image
Cupcake1971_Moderator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.