At times I itch like crazy, I know I have two blocked bile ducts again. PBC is a slow progressive disease so we know that has not returned. Most likely causes are bad blood supply to that part of the liver during the TX or it got damaged as they put it in. The problem may get sorted in the near future. Meanwhile has anybody had any side effects from taking Prograf. I have a burning sensation like sunburn and flakey skin on the face, my face goes red and stings like sunburn.