I'm at a loss. My mother was told she had PBC about 3 years ago following months of inexplicable full body itching. From my research, it is unclear to how many of those diagnosed suffer itching on this scale, but it is taking over her life. She takes Urisidol, but other than that has tried various other remedies all to no avail. She cannot sleep, she cannot function, she has scars and scabs all over from the scratching. She frequently turns to antidepressants and alcohol to dull the constant itch. I can't say I blame her, but I know that she is only continuing to harm herself this way. I'm worried sick and was wondering if anyone out there has ever encountered this, or has any treatment plans or words of wisdom to give. Anything will help, thank you so much.