ARE THERE 2 DISEASES, ACTIVE PA AND INACTIVE PA,

[tracyxyz]

[Hidden]

I supose one can say there is a condition called PA, and with good treatment it is in remission...inaddequate treatment seems to cause PA symptoms to come back..Marre.

[tracyxyz in reply to Hidden]

Can you please answer the following question completely. I was diagnosed with b12 deficiency after having over 70 saliva swabs , we worked out I needed active b12 which I recieve in a sublingal spray, I believe there is no active b12 in the injections so I did not think they could be in any way adequate. My PA is being treated by active b12 and I cannot understand how some people withPA are being treated with injections., regards Tracy

[Hidden]

Hi Tracy,

I can not answer everything correctly, I'm only a patient with PA...But from my limited understanding Active B12 is holotranscobalamin, this is not available in a spray etc, but only what the body has managed to convert B12 into say. To get a detailed view you will have to read up a bit, this link is easy, see:

active-b12.com/

I'll try to give my version of B12 preparations as I understand it:

There are 3 types of B12 preparations say for treating B12 def/ PA (besides adeno):

1) Cyanocobalamin (widly used, stable, cheap, but the body needs to convert it to become hydroxocobalamin, take off the cyanide molecul, then from hydroxo on it methylates it to two types of B12, methylcobalamin and adeno cobalamin. That is if all is working well).

2) Hydroxocobalamin (ls retained in the body for longer, is more expensive, less long shelf life than cyano. Hydroxo is converted if all goes well into methyl and adeno cobalamin)

Hydroxocobalamin is also used (in large quatities) for smoke inhalation (cyanide poisioning), as it attaches itself to cyanide say.

3) Methylcobalamin (The most natural form of B12, needs no converting, is most expensive, shortest shelf life, eeasily converts back to hydroxo if stored wrongly. Not licensed in UK.)

Some people do better on any of these 3 types, some people have problems with take up of B12 only (no IF) , but no problem transporting it (R binders), others have problems methylating it say, may all be genetic, but that is far to complicated for me to explain!!

I hope this helps,

Kind regards,m

Marre