Clotting

[tomdickharry]

Since taking over my PA treatment with frequent injections, my symptoms have greatly ameliorated.

However, there's one thing I hadn't anticipated.

Recently I've had to have a couple of teeth extracted. Each time I've ended up in casualty because the bleeding wouldn't stop, and wondered about B12.

Today I saw an article that stated B12 deficiency causes clotting. I'm wondering if the converse might also be true, that high B12 could prevent clotting due to lowered homocysteine.

Any observations or experiences would be welcome.

[Technoid]

If enough B12 is available, homocysteine is recycled normally and excess B12 would not affect it. I could not find any information on low homocysteine being linked to slower clotting times. Are you taking any medications or supplements that would affect clotting time?

[WIZARD6787]

If it did affect clotting times it would not be know due to the incomplete study done and for the most part not concerned with severe symptoms.

I have had experiences of both more profuse bleeding at times and unexplained bruising.

Good on you for effectively self treating. I am assuming you are self treating as symptoms have greatly ameliorated.

Homocysteine is not completely understood so that could have an effect.

[Jillymo]

In 'very rare' cases clotting has been reported.........

How does homocysteine affect clotting?

High homocysteine levels in the blood can damage the lining of the arteries. High levels may also make the blood clot more easily than it should. This can increase the risk of blood vessel blockages. A clot inside your blood vessel is called a thrombus. I have had none to date albeit I do suffer with the bleeding gum issue,

I am diagnosed with sticky clotting blood ( APs ). Other than the normal B12 symptoms I have not suffered any clotting event due to my PA or self injecting on a daily basis. My heamatologist to my surprise new nothing about a B12 deficiency or of it's symptoms ! But then saying that none of my consultants seem to have a clue when it comes to treating my B12.

This was a trial carried out some years ago which shows it has been studied.... ashpublications.org/blood/a...

Now in contraverse......... ( note bleeding from the gums )......... drugs.com/sfx/vitamin-b12-s...

I assume it to be to do with lack of platelets or too many ?

[tomdickharry in reply to Jillymo]

At the moment I don't know the answer. My memory is still badly affected, and it is more than sixty years since I studied. When other things permit, I will look into it. Maybe in a few days....

[Jillymo in reply to tomdickharry]

I understand the fuzzy head and memory thing, I get it too. This old age isn't all it is cracked up to be. We can do nothing other than take it all in our stride.

[Oneash]

Are you taking aspirin for the pain?

[tomdickharry]

No, I avoid all painkillers unless absolutely necessary.

[Technoid]

Throwing things at a wall here a bit but:

* You have no history of blood clotting issues?

* No liver issues?

* You're not on warfarin or some other blood thinner?

* You're getting enough Vitamin K?

* You're not taking very high dose EPA/DHA or fish oil?

[tomdickharry]

No, nothing applies. The only possibility, as far as can be seen, is the change in B12 levels. From lowest at 111pg/ml, on NHS treatment at about 400, through 1750 on monthly treatment, to totally unknown level on two by 1500µg injections a week. On the first two, I just did not bleed at all, just a jelly-like ooze for a few seconds, to bleeding that's hard to stop, even with plenty of K. Only action I can think of is to increase vitamin K or reduce injection frequency. There are still brain problems to overcome before cutting down, and I definitely don't want to involve doctors if at all possible.

[Technoid in reply to tomdickharry]

Honestly if you have an unexplained bleeding disorder, that's really something I would go to the doctor about because there may be a serious cause which needs to be identified and treated. I don't think it's related to B12 injections, there is no plausible link. I wouldn't experiment with anything modifying bleeding or clotting times until you get a better idea what might be going on.