I was diagnosed with PA 3 years ago. It runs in my family. I took loading does of methylcobalamin then went to once a month. No doctor ever told me to take folate or adenosyl. I recently learned that folate is a vital co-factor. Started 5 mg folate daily, loading doses of cyanocobalamin daily for 2 weeks. I'm now injecting every other day & continuing the folate. (Also have hypothyroidism).
My question is, recent blood work shows my neutrophils are high (79); & my lymphocytes are low (12.4). I have no infection that I'm aware of. Should I be concerned?
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Auburn9144
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Sorry I can’t answer your query about neutrophils and lymphocytes , but I would advise against 5mg of folate . ( vitamin B9)
That’s a massive dose that should only be taken for a short time for a case of extreme deficiency. A 400mcg dose is more appropriate and totally safe ( advised in pregnancy) You can overdose on folate , but not if it is taken in it’s natural form in fruit and vegetables
I recently read this hypothesis in a paper on the dangers of excess folic acid:
"We hypothesize that excessive intake of folic acid depletes serum holotranscobalamin (holoTC), thereby decreasing active vitamin B-12 in the circulation and limiting its availability for tissues. "
I would advise to supplement only as much folic acid or folate as is needed to get levels up into a good range ( high-normal) based on labs. A common maintenance dose based on multivitamin amounts is 200-400mcg folic acid. You may need more or less but I would advise testing first.
No doctor told you to take adenosyl B12 because in theory all the human-usable B12 forms are equivalent in tbe way they're used. In practice, some get on better with some forms than others (less side effects), some are retained longer in the body and there are suspected genetic conversion efficiency differences. But in theory they are all broken down to the base cobalamin molecule and used in the same way.
I'm intrigued that you got methylcobalamin injections, was this privately in the UK? AFAIK only hydroxocobalamin is used by the NHS.
in uk we have have doc too give permission hes taken off everything I gone down too 6 stone uk is dangerouse since stopping everything I have lots infections
Yes , you are right . Cynocobalamin works perfectly well , and is cheaper than Hydroxocobalamin. But, it should be avoided if the patient has Leber’s disease ( eye-condition)
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