6 days ago I found I have covid symptoms . Next day in the morning I had collapse and fall and my family saved me, then other covid symptoms showed up like sever sore throat,fever chill, losing appetite, body ache.
Due to B12 deficiency I have many B12 related symptoms like double vision blurry eyesight, stomach muscle severely strength less whole body extreme fatigue and weakness especially in right right,lower and upper back and arms shoulders.m y symptoms was started to get improved because of injection for about one year.i inject hydroxy and cyanocobalamin along with each other and taking required vitamin pills. But I learned cyanocobalamin depletes glutathione which is required to fight infections. Now this COVID infection caused extra fatigue and now I can't even sleep.
I don't know what to do . Please help.
I had two times Pfizer vaccine injection. Last one almost eight months ago.
I read in some people this fatigue stay for long time
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Hamayeshguy
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My hydroxocobalamin ampoules are limited and asked a friend to buy it for since no delivery take place in my spot. I think if I inject half and keep the other half for the other day in the fridge may work better for me. I asked private hospital for MRI. I think my symptoms related to covid a little bit is improved but this fatigue don't let me sleep even an hour. Before this COVID I had impressive improvement but after this COVID infection mostly relapsed my B12 symptoms. I was even attending my brother's office and was able to help him but now I have no clue when I'm going back to normal life again. In the meantime I can't inject cyanocobalamin since it depletes glutathione which is so important in fighting infection. Someone told me acetylcystein and gelatin powder and some physical activity help body make glutathione. But acetylcystein affects lung too and also liver. Please share your information
Firstly, sorry to hear of your relapsed symptoms and I hope you will start improving again soon. On the topic of Glutathione, I have not read anything that suggests that Cyanocobalamin supplementation will deplete it, can you share a source? From what I've seen/read, direct Glutathione supplementation, depending on the form, is either useless or dangerous. I wouldn't touch anything like that without good medical evidence that its an issue. Heres a video that discusses Glutathione a bit (but in relation to aging) : m.youtube.com/watch?v=rdOJa...
Can anyone guide me regarding dividing half of hydroxocobalamin and keep the rest in syringe in the fridge for the other day injection. In the meantime I tried to buy methylcobalamine from India but requires prescription band underground market price is high. Many countries in Asia are methylcobalamine ampoule manufacturer but all are expensive band requires prescription. So I asked Oxford for dry form but the problem is to have sterile penicillin like dark glass with proper cap ( special capper tool is required) and I think oxford just don't send in those glasses. And it requires to divide powder in those glasses in order to keep it active at the same time requires ph adjustment to have less pain in injection. And it's just IM no subconscious.For cyanocobalamin requires to take acetylcystein along with gelatin powder which is degraded form of collagen. Any information? please
When I was injecting hydroxocobalamin, I always divided the ampoule into 2 syringes, and injected them 12 hours apart without issue. I stored the 2nd syringe in the fridge in a foil bag. I made a youtube video showing the process youtube.com/watch?v=ORbEcIV...
I asked the German company the sells methylcobalamin ampoules (I forgot the name of the company, but others have bought from them also) if I could store a syringe of methylcobalamin in the fridge overnight for 24 hours, and they were not too keen on the idea but said it was possible.
I don't think the article from perniciousanemia.org is giving accurate/up-to-date information about Cyanocobalamin's effect on Glutathione. They couch their claim as: (cyanocobalamin) "could potentially deplete glutathione (GSH)". They then reference a 1990 paper : pubmed.ncbi.nlm.nih.gov/235... that does not claim any reduction in Glutathione levels from Cyanocobalamin, but merely hypothesizes :"we propose that GS-Cbl (Glutathionylcobalamin) or a closely related thiol-cobalamin adduct is a proximal precursor in cobalamin coenzyme biosynthesis".
However a more recent 2008 paper claims that, from experimental testing (not an untested hypothesis), that Glutathione is NOT involved in this process:
"The mystery of how the cyanide group in vitamin B12 or cyanocobalamin, discovered 60 years ago, is removed, has been solved by the demonstration that the trafficking chaperone, MMACHC, catalyzes a reductive decyanation reaction. Electrons transferred from NADPH via cytosolic flavoprotein oxidoreductases are used to cleave the cobalt–carbon bond with reductive elimination of the cyanide ligand"... "Although glutathione was reported to be required for decyanation of CNCbl catalyzed by cell extracts (17), we find that its presence (at a concentration of 1 mM) is without effect on either the rate of decyanation or the product that is formed (data not shown). Unlike titanium citrate, a low potential reductant (18), glutathione is unable to replace the NADPH/diflavin oxidoreductase system as a source of reducing equivalents for decyanation of CNCbl by MMACHC (data not shown)."
Returning to the perniciousanemia.org article , there is this strange paragraph:
"It takes more than 48 hours for cyano B12 to convert to usable methyl B12. Even then, only a small amount is converted. Remember, in this conversion process, it requires the interaction – possibly the depletion – of glutathione and other agents. For that reason, it can make Leber’s optic atrophy worse, and nobody should ever use it in that case."
The speed of conversion of cyanocobalamin to other B12 forms and any interaction it has with Glutathione has absolutely nothing to do with its effect on Leber's disease. I think they are just throwing everything they can at cyanocobalamin regardless of whether it even makes sense or not.
Finally the sites credibility is seriously damaged by the fact that they sell B12 injections and only of methylcobalamin....so of course it makes sense that they would want to cast all possible doubt on cyanocobalamin while singing the praises of methylcobalamin!
However it IS fair to say that methylation does need good support during the B12 treatment process, particularly in the areas of Folate, B2 and B6, Choline/TMG, Serine/Glycine and Taurine. Adenosylcobalamin production also needs to be supported by adequate Biotin. Magnesium is required for the conversion of methionine into SAM by the enzyme methioninadenosyltransferase (MAT). I mention all these nutrients/mineral in my recent post on B12 treatment guidance regarding supplementation.
I found an additional piece of information about Glutathione, it seems no matter what form of B12 you take, you're going to need adequate Glutathione since its needed to turn base Cobalamin into the active forms.
"Intracellular reduction of the central cobalt atom is essential for the formation of the metabolically active forms of B12. This process requires reduced glutathione and the hydroquinone form of flavin adenine dinucleotide (FADH2), it is therefore compromised by oxidative stress. In such conditions treatment with glutathione and/or vitamin C, a key physiological regenerator of intracellular glutathione, may provide therapeutic benefit. This warrants further investigation."
Thank you but, is it possible to raise glutathione levels in our body just by increasing precursors like gelatin and acetylcystein ( or acetyl glycine)
Hamayeshguy, did you watch Brad's video? It has some useful info. Some ways that may help to increase Glutathione levels (if they are low) are listed here: healthline.com/nutrition/ho.... I would focus on diet and improving sleep as the no.1. If you do feel supplementation is needed, I advise to check with a doctor before taking any supplement, check for contraindications with any other medicines or supplements you take, or pre-existing health conditions, and staying within recommended dosages. You could consider N-Acetyl-Cysteine at 600mg to 1200mg a day. More info on N-Acetyl-Cysteine : verywellhealth.com/the-bene.... Bear in mind that a cysteine deficiency is rare so I would not advise to take the NAC long-term but only for temporary support. You don't need Gelatin since Glycine supplements are readily available, or you could just make sure you are getting adequate Glycine from diet. If you do take Glycine, 1-3 grams of Glycine supplementation should be enough, wouldn't advise going much higher than that.
But glycine raise systolic blood pressure in men but no difference in women however There are some conflicting results in those studies. Acetylcystein has some detoxifying effect on liver for acetaminophen overdose and also break tick mucus of lungs and help in some lung diseases. Gelatin is also blood extender and too much can raise blood pressure
Like I said, please be aware of contraindications with pre-existing health conditions such as pre-existing high systolic blood pressure. Excluding pre-existing conditions and other contraindications, short-term supplementation of 1-3 grams of supplemental Glycine will not harm your blood pressure. I am not advising you to take these supplements without guidance from a doctor. The point of gelatin in this context is that it contains Glycine which is the important component for Glutathione support. Gelatin is not necessary in and of itself.
You may be on the right track with indirect support of Glutathione to combat COVID-19. Check out this paper regarding how COVID affects one carbon metabolism. The conclusion was:
"data discussed in this review suggest that therapeutic interventions aimed at normalizing glutathione, Met sulfoxide, and choline might provide a promising approach to combat the COVID-19 pandemic. Glutathione can be normalized by supplementation with N-acetyl-Cys [71], or more effectively with Gly + N-acetyl-Cys [28] which, by reducing oxidative stress [28] should also normalize Met sulfoxide. Supplementation with choline can restore its normal levels [72]. Further studies are required to determine the therapeutic potential of targeting these metabolic areas." mdpi.com/1422-0067/23/8/418...
Reduced Glutathione caused by COVID-19 would likely affect how efficiently you can turn B12 into it's active forms, so a symptom relapse makes sense. Although research is still preliminary, seems worthwhile looking into this treatment track of NAC and Glycine, Since they also mention Choline support. Alpha-GPC to support Choline could be a good addition to the stack.
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Update - 8 weeks of injections and some new symptoms
a question about symptoms being really bad then better day to day
New symptoms following injections
One day On, another day off while on B12 injections
New symptoms after self injecting?!
