Interesting report suggests overexposure to cobalt can risk cardiomyopathy.
Worth noting
urmc.rochester.edu/encyclop...
Note: edited by admin to replace reference to B12 with reference to risk of cardiomyopathy
quoted article conflates B12 and cobalt. Cobalt is an important constituent of cobalamin but is very tightly bound in the molecule. The risk with cyanocobalamin and Leber's relates to the cyano element in that form of B12.
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A bit late for me after B12 injections every month for fifty years
Once a month seems unlikely to cause harm.
Its every day that may be too much
Sorry, but as per my reply elsewhere in this string, I beg to differ! Please provide peer reviewed research evidence to support your statement.
You're a very fine example of a B12 success story clivealive . And long may that continue xx
‘It's every day that may be too much'
Your statement is potentially misleading and alarmist - especially for those who have no option but to inject B12 every day to remain healthy. Please can you post relevant peer reviewed research evidence to support your view that injecting vitamin B12 'every day may be too much'.
Note: information in the link you provide states:
Medically valid uses
As part of B-12, cobalt is used to prevent pernicious anemia. It’s also needed to keep the nervous system working well.
Please see this from the respected B12 research institute in the Netherlands, who work closely on research projects with the Pernicious Anaemia Society…
stichtingb12tekort.nl/weten... (B12 Treatment Safety / Long Term Treatment for neurological symptoms)
BNF (prescribing guidelines for medics) for those with neurological symptoms 'B12 injections every other day until no further improvement'.
‘Cardiomyopathy from overexposure to B12' - I think not!
A very rare few may have a sensitivity to cobalt but that is an entirely different matter - and would not lead to cardiomyopathy.
Sorry, but as I said above, your statement is both misleading and alarmist!
The paper is issued by a highly respected academic institute in the US. It does relate to cobalt, but cobalt is the key component of B12.
The issue is, no-one has evidence of the bounds of overuse. BNF may recommend every other day, but if there is 'no known toxicity' then why is it not daily?
Clearly EOD injections are BECAUSE there is a risk of toxicity otherwise. And that risk includes cardiomyopathy.
For some people with PA, they may need to manage falling b12 levels with daily injections.
But for those without PA, there is clearly a risk of overdoing it despite persistent symptoms.
This forum appears on the NHS website under 'B12 and Folate anemia' and the conversation should include B12d not just PA. Especially at a time when people are vwry vulnerable and struggling to get blood tests or proper responses from medics.
If there are risks, they should be highlighted.
It is then up to the individual to decide to weigh them up.
I do sense that were in dangerous territory to suggest 'there is no way to overdose' when injections are recommended as every other day and there are risks to too much.
If this is my last post I hope it helps someone else make an informed and educated decision on self treatment with clarity on the risks.
If you've been SI everyday then please carry on.
If you haven't, please can this forum provide more detail and clarity on the risks of self injection. Because they are there.
Point of reference…
The only point I am going to make here is that every day injections are not advised simply because of the high rate of excretion of B12 via the kidneys (much will be wasted) - not because of the risk of toxicity.
Once again you make assumptions based on personal conjecture.
You have been advised elsewhere in this forum NOT to self inject vitamin B12. I hope you have followed advice and consulted your GP about your B12 deficiency. This needs treating by a medical profession so that you do not come to harm.
The article you have linked to is very poorly worded. Not differentiating between cobalt and B12.
There was some discussion on this same topic here:
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How do you treat B12 deficiency with cobalt allergy? 
Hello
Reaction to B12 tablets 
MMA and iFAB tests
