PA/MPN correlation

[Kittywithin]

Hi there! I have been having B12 injections every 3 months for the last ten years or so. I was recently diagnosed with MPN ( though I don't have the Jak2 mutatation) . My bloods have been 'odd' for many years, but I was only diagnosed with MPN when I changed surgeries a year ago. My new surgery are doing the 'watchful waiting' approach, which I understand, but my B12 bloods were 167 at my most recent test. I just wonder if anyone knows how much correlation there between PA and MPN? Is there anything I should be asking my GP about? Or is watchful waiting the answer. Thank you folks! Best wishes to you all!

[Nackapan]

167 seems very low on b12 injections perhaps 2 monthly would be better? MPN I've not heard of ...will await others to enlighten me

[Kittywithin in reply to Nackapan]

Hello.! Thank you for your response, I think I will have a word with my gp to see if they will increase the frequency . And , sorry, MPN is myeloproloferative neoplasm. My GP is very lovely, but always suitably vague whenever I ask about it

[Hidden]

MPN is often associated with B12 deficiency, folate deficiency and iron deficiency anaemia. Your GP has done extremely well to have spotted it which suggests they’re pretty good. Your b12 is very low for someone on injections even as far apart as 3 months and that may be something to do with your diagnosis. If it were me I’d be asking for a referral to a haematologist and I’d want to know more about what the plan was and why watchful waiting is appropriate.

[Kittywithin in reply to Hidden]

Thank you very much Martin, that's really useful to know! I absolutely agree that they were very good when they picked it up, my previous GO's often commented on my iffy blood results over the years , but never really looked into it until I moved to my current surgery. Next time I go, I will definitely enquire about a review with a haemotologist . Thanks again

[jointpain in reply to Kittywithin]

Maybe join the mpn voice forum here on healthunlocked. My wife has Myelofibrosis (an MPN)

[Kittywithin in reply to jointpain]

that's great, thank you, I'll certainly check out the Mpn forum.

[fbirder in reply to Hidden]

I can't find any association between MPN and B12, except that it seems MPN might cause high levels of B12 and a functional deficiency. sciencedirect.com/science/a...

[fbirder]

167 is very low for somebody injecting. Was that a normal serum test or an Active B12 test?

[Kittywithin in reply to fbirder]

Hi there. It was serum B12 level. My serum folate was also slightly low at 2.3. The test was done literally just before I had my 3monthly injection , so that could explain it? I've never heard of an active B12 test? This forum is very enlightening 🙂

[Hidden in reply to Kittywithin]

I’m not sure but there is a connection between B12 low folate and IDA and that’s why I think you need a medical opinion. There appears to be some evidence that correcting your levels will help with symptoms but I’m not a medic.

[EmfiTa in reply to fbirder]

HiDo you know what b12 should be if injecting regularly, say once a week. I'm PA. Thanks

[Hidden in reply to EmfiTa]

It will be different for everyone but after a period of several weeks I would expect it to be over the top of most lab ranges. I know mine is.

[Skeeter1956]

Hi Kittywithin you might want to join MPN voice , another site on Healthunlocked . It might be of interest to you , if you are not already a member .Best wishes Skeeter .

[Kittywithin in reply to Skeeter1956]

Thank you very much, it was mentioned by another member, and I'm very grateful to have found this site 😀