Feel Bad After B12 injection - Pernicious Anaemi...

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Feel Bad After B12 injection

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Hey, So i had a B12 injection today at 11.30. As soon as i had this injection i felt little rush of dizziness. nothing major compared to the dizziness from being low in B12. my face automatically went a little red. (Nurse commented on this) and ever since i keep getting adrenaline like dumps in my body. Not a panic attack as don't get sweats, fast heart rate or anything. It basically feels like my brain dumps adrenaline and then 10 seconds later i'm fine. Spoken with Gp who said she has never heard of anyone reacting to it like this. My question is, is it normal to get this "anxiety," Increased tiredness and dizziness after an injection. Not sure if i want to go for the rest now.

Thank you :) xx

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55 Replies
Nackapan profile image
Nackapan

I've had 'reaction s'

See how you feel in a day or so.

Wrongly or rightly I felt at times it hit my system too quickly and I felt overwhelmed. Clivealive describes it like a radio suddenly picking up a signal too loud and clear.

At the beginning o certainly got alot worse before better.

Was your vel very low?

Are you having nasty symptoms from deficiency ?

Nackapan profile image
Nackapan in reply toNackapan

Level of b12 very low?

in reply toNackapan

Thank you for your reply. My level was 210 which is not considered low at my gp. But I have numbness and pins and needles, dizziness, brain fog

Nackapan profile image
Nackapan in reply to

The reason I asked as mine 106 and wondered if ' traction was been so low for so long probably body shocked.

You could still be feeling that though as serum b12 tests show all b12 so some not 'active'

Ask for a referral to a neurologist.

in reply toNackapan

Wow yours was low. Have you had treatment? How do you feel? May I ask why a neurologist?

Nackapan profile image
Nackapan in reply to

I'm 18m in.

Still having regular b12 injections.

Pins and needles and dizziness are neurological symptoms and should be checked out.

Ask your Gp.

HopetoB12better profile image
HopetoB12better

Keep pressing on with your injection schedule. I felt a little worse before I started to get better. It really sounds like some type of anxiety if it happened that fast after the injection. I was scared to death of the first one but now I look forward to them because it gives me a mental rush because I know I will keep feeling better!!

in reply toHopetoB12better

Thanks for reply. It’s not the first time it has happened. I had injections last year and the doctor stopped them as they think I reacted to them. I had 6 “episodes” I’ll call them since my b12. It’s feels like the feeling u get when your scared.

HopetoB12better profile image
HopetoB12better in reply to

Adrenaline rush? Maybe it is that from the thought is the injection?

in reply toHopetoB12better

Can low b12 cause these anxiety symptoms? And injections be making them worse or am I now dealing with anxiety? X

JanD236 profile image
JanD236 in reply to

I’ve read on this forum that low B12 causes anxiety for some. Also that one form of B12 (methylcobalamin) causes anxiety for others. If you had your injection at a UK GP practice you will have been given a different form of B12, hydroxocobalamin, and I’ve not heard of this being linked to anxiety.

Nackapan profile image
Nackapan in reply toJanD236

No I havent either.

I had anxiety as a symptom of b12 deficiency. That has now gone now with regular injections. Was new to me and was wondering what was going on.

The adrenaline rush I've also had. They nearly stopped mine at the start but I asked to continue.

I rarely get that rush now and If I do it passes.

So do carry on michellep1990 if you can to see if they help you.

in reply toNackapan

So you go the adrenaline rush after the injections or before? I shall carry on give it a bit longer to see if it helps

Nackapan profile image
Nackapan in reply to

The worse time wad my injection wad at 1530 and ad the b12 peaked in my suste it happened. Never before. I also can get hot flushes

Different from menopausal flushes I donr have.

It's only happened once recently when my head felt like a pressure cooker on speed if that Makds sense.

What was odd wad the injection did not hurt but wad deep . I think it not in so quickly . I thought it was a different make of Hydroxocobalamin. Even rang the pharmacist.

He thought it was what I've now been prescribed as different to what's usually use by te nurses. So I set injected expecting a reaction. Brave I thought butneedrd to know. Nothing. I have 3 sorts of Hydroxocobalamin. I'm told by fbirder they all so very similar in makeup.

So my conclusion is it's how symptomatic I am when i have it. How quickly it goes into my bloodstream. How low is my b12.

So man things .

My daughter goes to the surgery and had never had a 'reaction??

I can also get tinnitus badly after an injection. I used to call it the b12 buzz. This rarely happens now .

I've only once had the feeling of go go go. It lasted a day then I crashed??

Hope that helps

Initially I had constant headaches and injections brought on worse pain. Again rarely.

Nothing else has helped my symptoms and nothing else has been found wrong with me.

Nackapan profile image
Nackapan in reply toNackapan

Sorry vision down today

*peaked in my system

Milley2 profile image
Milley2 in reply toNackapan

I get this buzzing tinnitus after injection

How often do you inject now

I seem to not be any better

My folate level is good

But mon I injected that eve was on the floor

Didn’t inject tues or wed

By thursdsy again I was in the floor

So injected at 2pm was a little better then next day was good

Then into the eve I was awoke 1am by feeling sick

Ear hissing flu like symtoms

Weak shaky ?

I’m so scared it’s something else

It I should be doing daily and let mysrlf deplete to much if days when I dint do

The head thing is vile is buzzing noise constant yet yest didn’t have at all

Injected this morning ive worsened ? A lot

I’ve had 2 hours sleep and can’t get to grips with this

I did have h pylori and was treated it gone now

But I feel so terrible

As if the b12 isn’t working no more or is it I take to much I can’t level it out at all

Any thoughts or help ?

Feel like I have a lawn mower in my head

It does not let up

Yet yest it went

Today it’s back

Please help any advise

Vit d level is good snd when I’m like this I can barely eat

It’s vile

Nackapan profile image
Nackapan in reply toMilley2

Yrs sound familiar. I'm on every 6th day at present.

Thd tinnitus initially was like yours. Not ad bad now . Always present when using short sight like now! K get pain behind my ears and in my jaw. Its always there but in lesser degrees again sm improvement ad used to have daily headaches varying from migrain/chronic cluster. The neurologist said nichdl muscked continuously contracting .

Mh kull gets very tight

I eat well and do push through if nauseous as food helps me. I do manage with distraction techniques alot of the time bug it's hard sitting still ag times ad cant use my eyes much without a consequence

Nor sure how long youvd been having injections?

It does improve bug dor mr z rollercoaster. Nog had s symptom free day yet but forever hopeful.

Milley2 profile image
Milley2 in reply toNackapan

Thanks

B12 since July

Had loading then monthly now I’m having to inject myself getting scared but I’m so much more symtoms than I ever had

Nackapan profile image
Nackapan in reply toMilley2

Hang in there and keel a diary.

Milley2 profile image
Milley2 in reply toNackapan

Yeah I have since June

There’s more symptoms all the time

Wasn’t like this initially

Jydt had minor ear hiss and sickness now I’ve lots more issues

But when I dint take b12 I’m literally on the floor I was at 124 level

It’s increased now surely but I can’t see improvement only worse

Consultant said monthly b12 is enough

But if he could see how I live daily although I told him he saud he hasn’t seen that snd it’s not b12 as I’m not defiency no more

It has to be some thing

I’m just not right and had every test possible

Nackapan profile image
Nackapan in reply toMilley2

Have you tried a higher frequency of injections. ?

JLB80 profile image
JLB80 in reply toMilley2

How r u now?

Parksy profile image
Parksy

Both my daughter and I react exactly like that after an injection. We just call it the b12 wake up to minimise it. I don’t usually feel better until after 24-48 hours. But I have to be honest and say we’ve both slipped with keeping up our co factors and as b12 needs potassium that’s probably why!!!

in reply toParksy

Thank you for your reply. How did you both deal with the adrenaline rushes? I feel like my anxiety got a lot more intense since taking the injections. Thought it may of gone this morning but it has not

Parksy profile image
Parksy in reply to

Both my daughter and I found that the old adage Of fear breeds fear to be very true so we both got a wholefood (pharmaceutical vitamins are trash) multi b supplement, up the potassium and take magnesium L threonate and magnesium glycinate. Plus natural omega 3’s which all help anxiety and adrenalin rushes. We did used to do the adrenal cocktail which really helps but because in the U.K. you can’t just ask to her potassium levels tested we only do it when we need it.

in reply toParksy

Oh ok I shall have a look into the information you mentioned. How long did your adrenaline rushes go on for after your loading doses may I ask?

waveylines profile image
waveylines

Try eating banas regularly whilst you are on loading injections. They have plenty of potassium in them. I was told to do that when I started. Also you need to make sure your folate levels & other bs are all good as the vitamin bs work together.

in reply towaveylines

Thanks for reply. I am eating 2 bananas a day it’s hard to get more food in as I’m really off my food at the moment. My folate was 8.3 which is considered normal x

StaceyNZ2020 profile image
StaceyNZ2020

Hi! According to my doctor you can create antibodies to the hydroxocobalamin which can cause a reaction (this happened to me, but is hard to test for).

He said a different type of b12 injection (I’m not sure of make up) might be better as the one I was prescribed was the generic one, there was another I could have but he’d have to apply for an exemption for it to be funded.

My last blood tests showed really high b12 so I’m not having the injections for 3 months and then checking again.

Sorry I know that’s vague as but I had similar symptoms to you (nausea, vertigo) the morning after an injection.

in reply toStaceyNZ2020

Thanks for reply. I shall speak with gp about it. Did you have bad anxiety after your injection? Well more anxious

StaceyNZ2020 profile image
StaceyNZ2020 in reply to

Not anxiety but certainly the rushes of hotness / dizziness - definitely feels like a panic attack or like you’re going to pass out.

My doctor didn’t know how to test for the antibodies but for me the nausea etc was so bad it’s worth putting up with the fatigue for now

in reply toStaceyNZ2020

Yes that’s like mine. Massive rush in my body then goes it’s like it’s trying to get into a panic attack but does not get there. What b12 do you use

Nackapan profile image
Nackapan in reply toStaceyNZ2020

It sholdnt go by numbers. Why are they testing levels. ? It should ho by your symptoms.

StaceyNZ2020 profile image
StaceyNZ2020

I’m in NZ - the front of the packet says Neo-B12 injection

Ingredients are listed as:

Hydroxocobalamin chloride 1.027 mg equivalent to hydroxocobalamin 1.0 mg

Sodium chloride 9.0 mg

Water for injections to 1ml

1 N acetic acid is used to adjust ph

Manufactured by Pfizer Australia

I hope that’s helpful!!

CatAnne24 profile image
CatAnne24

I had similar feelings of anxiety in the past after my injections and the nurse advised to make sure to be very well-hydrated the day of a scheduled injection. Also, I always drink a bottle of room temperature water (it absorbs better if room temp) within a few minutes of the injection. No more issues. Hope that will help you too!

Nackapan profile image
Nackapan in reply toCatAnne24

Yrs I drink alot of water.

briarhillcat profile image
briarhillcat

Well, I can understand how it made you feel, and it is not nice to feel this way. I have never myself had those symptoms after an injection, but had them before it was due. I know you cannot have too much B12, as the body throws out what is not needed. I hope you can get it sorted out, but it is very stressful at the moment with this Covid 19 and I think we are all getting stressed over it. I do not think it was an overdose of B12, so try not to worry about that, but maybe other people might have an answer. Just wanted to let you know we are all here for each other. Briarhillcat

MoKayD profile image
MoKayD

For the first 6 months I started receiving shots I definitely felt a "rush" almost immediately after getting my shot. My face would sometimes feel warm too. I thought everyone felt like that when they got a B12 shot. I kind of enjoyed the feeling because with it came a rush of energy. My husband would joke that I was having shots of amphetamine. I don't get that rush anymore. I guess things have healed and my body isn't reacting to it as much.

in reply toMoKayD

Thanks for your reply. I think we are talking about different rushes! My is an adrenaline rush not just when I have injection but also keeps happening every hour or so. It’s horrible and makes me panic! It’s like the start of a panic attack but not panic attack

MoKayD profile image
MoKayD in reply to

Can you feel your heart pounding kind of hard in your chest?

in reply toMoKayD

No I get palpitations but not same time as the adrenaline rush

MoKayD profile image
MoKayD in reply to

Oh, I'm sorry, that sounds awful. Hopefully your reaction will subside when your body heals some more. I can barely tell I've had a shot now unless I've waited too long to get it. I can tell I need a shot when the tip of my nose starts to feel cold. After I get my shot the tip of my nose feels tingly and warm

Nackapan profile image
Nackapan in reply to

I think that its your central nervous system having a shake up. Try and think of it as part of the healing.

Reembow profile image
Reembow in reply to

I got that with niacin

Trying2Bbetter profile image
Trying2Bbetter

Do you know what form of B12 you are receiving? Some tolerate cyanocobalamin much better than the other two forms. Methylated vitamins in particular cause me major anxiety problems so I avoid them at all costs. I would also check your labs and see if you have a recent potassium level.

in reply toTrying2Bbetter

Thanks. I’m on the b12 injection that starts with h. Also my potassium was 8.3

in reply to

No my potassium was 4

Trying2Bbetter profile image
Trying2Bbetter in reply to

How often are you getting shots? Potassium (and folate) deplete pretty quickly if you’re receiving frequent injections. If you’re having injections often and that lab was taken a little while ago, it’s possible that could be the issue.

I would see if your dr would allow you to try the cyanocobalamin b12 injection. That’s pretty much all they use in the US and I know some people think the one you’re on is superior but cyano is very well tolerated. Yours may be very effective but if you feel awful on it, I don’t think it’s benefits outweigh the side effects you’re experiencing. I really hope you feel better soon. It’s awful to feel sick and worse when the treatment doesn’t help. 😔

in reply toTrying2Bbetter

I only had my first one yesterday! Due my next one Friday! My bloods were done 2 weeks ago. Would they lower that quick?

Trying2Bbetter profile image
Trying2Bbetter in reply to

Oh no, they should be fine then. I was thinking maybe you were doing them every few days. I would ask about a different form and see if you tolerate that better. There is also a Facebook group called Pernicious Anaemia/B12 deficiency- support group and it may be helpful to you as well. Lots of people talking about their experiences with these same things.

Nackapan profile image
Nackapan in reply to

Dont take any potassium supplements as dangerous. Toh wi get plenty from food . Potatoes ect. If youd levels are within range dont worry . Just get your folate vit d ferritin and perhaus thyroid checked on next bloods. 400pmcg folic acid daily is more than enough. Gk by blood so toh dont over supplement. That can give horrid side effects if not needed.

Thyb profile image
Thyb

Have you tried 'Nature provides' - 2400mcg Bioactive B12..pure and vegan...Contains:- dual coenzyme B12 Methylcobalamin +B12 Adenosylcobalamin?

Just wondered !?

Av42 profile image
Av42

Always come home and drink 330ml coconut water after injection, disgusting but has potassium and very refreshing as always feel thirsty had heart palpitations and nervous sweats prior to loading and for 3-6 months after treatment began

My first injection was today... 1,000 MCG. I've been documenting my feelings. I first got dizzy then nauseous then anxious then my joints ached and my arms felt heavy. About a half an hour ago I got a brief headache. My shot was 6 hours ago. I am hoping that this will end after a good night's sleep. It's 7:00 p.m. right now in Ohio. I'm looking forward to sleeping through it and waking up feeling better. Fingers crossed. Hope your side effy do not last.

KBird01 profile image
KBird01

I had similar symptoms, including tinnitus and dizziness, particularly at the beginning. I managed this by cutting down the dosage and now just use 0.6/0.7mg out of 1mg injection. This seems to give me the right dosage, without the side effects. I am quite small at 4'11 and 9st though, so maybe it is to do with my weight/size. Good luck with your recovery.

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