I’m asking some advice for my friends daughter who I’m convinced has a b12 problem.
5 yrs ago she was very ill and diagnosed with CF( (all started after a trip to Africa). She then started having awful migraines and has been rushed to a&e a few times as they thought she’d had a stroke but drs said it’s the migraines (lost feeling down one side of her body). She now feel nauseous 24/7 and had lost loads of weight.
Last year her serum b12 was 177ng/l but gp wouldn’t treat as range started at 170.
Had a retest 3 mths later and it was 196 so gp said fine definitely not b12 as it had increased.
Now she is 18 she just had private tests at Viapath
Serum b12 is now 300 so gone up.
Active b12 was 128 over the top of the range (top was 112)
MMA was 110 ( in range top was 150)
Homocysteine was 12.5 ( top range 15)
Folate was 10
She hasn’t taken any supplements or had any injections and she is hardly eating so all very confusing as to why serum levels have increased.
Does the fact her active b12 is above range suggest it’s not being used ? could this be something to do with the mentyl gene? (I’ve read stuff about MTHF mutations but don’t really understand it).
There is also b12 deficiency on the female side of her parental grandmothers family.
Can anyone advise please.