Congenital Deficiency of Intrinsic Factor and Pernicious Anemia

[dgnvb21144]

Hello!,

New on this site.

Is Pernicious Anemia and Congenital Deficiency of Intrinsic Factor the same illness?

Thank you in advance for any information provided.

Dona Gray

[clivealive Forum Support]

Hi dgnvb21144 if you don't produce Intrinsic Factor or you do have Intrinsic Factor Antibodies you will not be able to absorb Vitamin B12 via your digestive system and you will have Pernicious Anaemia.

I hope this answers your query but if you have more questions please don't hesitate to ask as there are more learned people on here who will be able to help.

I am not a medically trained person but I've had Pernicious Anaemia (one of many causes B12 deficiency) for more than 46 years.

I wish you well.

[dgnvb21144 in reply to clivealive]

Thank you so much!

I inject because my neurologist explained that all the B12 tablets in the world taken orally will never help me. Intramuscular injection once monthly.

I also have a mutation in the GIF gene(Gastric Intrinsic Factor gene), and multiple mutations in TCN(Transcobalamin Network gene)which impacts B12 absorption.

[Melbourne-Girl in reply to dgnvb21144]

Intrinsic Factor is a protein produced in the lining of the stomach. It is essential to bind with any foods you have that contain B12. If you do not have any to bind with B12 then you will automatically have pernicious anaemia. It is after binding that it goes to the

Intestines to be used. I hope that makes sense. For your red blood cells to be normal & work in the body properly you need the intrinsic factor. As you have never had it you

would be on injections of B12 for life.

Have you got a good Dr that you can talk to about this? This is a great site for getting information about pernicious anaemia. Many patients inject their own B12 and it can be injected as intramuscular in the thigh or as sub cutaneous in the tummy (you need much smaller needles for your tummy injections).

Some people find it easier in the thigh while others find it easier in their tummy.

FYI you are not supposed to have your full name on here for reasons of privacy to you. I saw both a Christian name & a Surname on your site. If that is your real name I would either change it completely or include your Christian name into your name on site,

Wishing you all the best xx

Melbourne-Girl

🍀🍀🍀🍀🍀

[dgnvb21144 in reply to Melbourne-Girl]

Thank you!

[fbirder]

Are you sure you have congenital IF deficiency? It is incredibly rare - just 100 cases ever reported in the whole world. And only half of them confirmed biochemically. It's normally detected at a very young age.

It's not the same as PA, but the effects are the same. As is the treatment.

[dgnvb21144 in reply to fbirder]

That is what is listed in my patient portal account via my neurologist.

I have an appointment again in December, and will be sure to ask her fir info and details.

Thank you!

[dgnvb21144 in reply to dgnvb21144]

Oops!,

"For"