High B12 after shot

[Hormone-mess]

Hello! I was diagnosed with Hoshimotos/hypothyroid in January of 2015. Then diagnosed with autoimmune premature ovarian failure a year later. At the time of hypothyroid diagnosis my b12 was 312. I was told to supplement with a methylation B12. I have on and off supplemented with a fairly large dose since that time. I had another blood test on April 8th that showed a level of 387 pg/ml. I went in for a B12 shot on May 23rd. I had a blood test on June 5th almost two weeks after the shot. I am now showing over range B12 of 1452 pg/ml on scale of 232-1245. Why would it still be high? I thought your body quickly utilized it and excreted the rest in urine. I’d appreciate knowledge you all have. TIA

[Hidden]

Yeah you'd think so, right? But nothing in the B12 journey of discovery is as easy as that The NHS keep saying I'm OK because my levels are high but if your body isn't using it properly then you can have loads in the serum readings but still be experiencing issues. As for how long it takes after supplementing to get 'proper' readings, I've heard figures of around four months.

In the "Could it be B12?" "movie" (b12deficiency.info/films/) Sally doesn't even do the B12 test but instead the MMA and Homocysteine as if they're raised it can show the B12 isn't being utilised properly.

I found this relevant response from fbirder on another thread which provides more insight:

"B12 may be water soluble, meaning large amounts in the blood will get flushed out via the kidneys. But it is also stored in the liver. The liver will secrete bile containing B12 into the small intestine where, in somebody with normal absorption, it will be reabsorbed back into the body (enterohepatic recycling). That means it can take many, many months for the levels of B12 to drop.

Those of us with PA don't produce Intrinsic Factor, which is required to reabsorb the B12. So the stuff in our bile gets eliminated in the faeces."

[Gambit62 Administrator]

your kidneys will remove 'excess B12', ie B12 that isn't bound to either the protein that allows it to be stored in your liver or the protein that allows it to pass into your cells, but they can't do it instantaneously and just over 2 weeks is a pretty short period of time to expect them to have removed all of the unbound B12 - there is a lot of B12 in a shot - people vary in how quickly their kidneys remove the B12 but generally they remove 1/2 of the amount in your blood in 24-48 hours. After the shot your levels will have been well over the measurable scale - >6000.

Additionally some people respond to high serum B12 levels in a way that stops B12 passing in to your cells and that reaction also tends to mean that B12 stays in your blood longer.

[loves-dogs]

Out of curiosity, have you tried low dose Naltrexone (LDN)? They are having good results with it in the area of autoimmune and other diseases as well as allergies. At the starting dose of 1.5mg, it's already working very well for me.

[Hormone-mess]

No I haven’t tried it, although I have heard about it. I do struggle with my autoimmune conditions and have never felt well. I think I’ll do some research and run it past my Dr. Thank you!