Hello again. This has not been my daughters week. After posting about her seeming to regress after 10 initial loading doses ( not had the blood results back, but I think it was low potassium as now so much better after high intake of potassium rich foods and coconut water ) she has quite suddenly broken out in the small acne type bumps all over her face and some deeper painful spots. She had beautiful skin before this. I know from researching that the acne is caused by high doses of B12 increasing the amount of inflammatory toxins released by skin bacteria, and I will set up a dermatologist appointment to treat her skin. However, moving forward, she is to have one more weekly shots and then move on to monthly. I was wondering if anyone has thoughts on the merits of splitting the monthly shot in to two 500mcg injections fortnightly, rather than the 1000 all at once ? Its the same amount of B12, and wondering if a lower level flooding her system at one time may help control her skin ?