Log in
Pernicious Anaemia Society
16,713 members11,576 posts

B12 and metformin

Hi everyone,

I am new here.

I have PA and as a result polyneuropathy with practically constant legs pain. I am on B12 shots for about 2 years.

Now my endo asks me to start with metformin as my insulin ( 11) and leptin ( 40) levels are high.

I am really scared to take metformin as i know that it can affect B12 levels.

Or it doesn't matter if you get shots?

Thank you

4 Replies

if you are on injections for B12 then the fact that metformin interferes with absorbing B12 in your gut is not relevant as you are no longer absorbing your B12 via your gut.

In fact there have even been some studies that I have come across that suggested that metformin may help with processing of B12 at the cell level.

1 like

Thanks so much, Gambit62

1 like

I've had P.A. for 45 years now and I too worried when I was diagnosed with Type 2 diabetes a year or so ago and put on high doses of Metformin but as Gambit62 says because I'm on b12 injections the pills won't adversely affect my B12 level.

Do you know what your iron and Folate levels are as these work together with the B12.


Thank you, clivealive!

My iron is always very low as i have IDA for 40 years. Folate is OK.


You may also like...