I've been having B12 shots several times a week since mid November, many of my original symptoms have improved, tremors, muscle spasms, pins and needles etc. However many of the muscles that originally spasmed a lot are still very stiff, not as flexible as they used to be. More weirdly other muscles seem to be stiffening up that were previously okay. I had blood tests to see if there were any inflammation issues, and these have come back clear, my B12 and folate are also sky high. GP has agreed to continue with injections regardless, as some improvements have been made. Do other people find there symptoms change? It just seems odd that new muscles are getting stiff and immobile even though I'm having the injections.