Apologies for the length of this post but I just want to make sure I cover everythng!
I've finally bitten the bullet. The ampoules arrived yesterday so I dutifully trotted off to my local needle exchange and obtained the necessarily paraphernalia and came home, shaking like a leaf and feeling a bit like a junkie if the truth be told.
I prepared everything (I would give an account of the mistakes I made and make you laugh but this post is long enough already!) I braced myself, the needle hovered for about three hours (well that's how long it felt anyway!) and I eventually did the deed.
It was such a relief to discover the pain in my right leg disappearing and the numbness in my left leg starting to recede. I actually walked up my stairs normally within 10 minutes of having the injection.
By the evening the bits that had un-numbered had started to throb a little (a bit like when a dental anaesthetic wears off) and I was so relieved I nearly cried. I slept for nine good hours last night without any pain waking me up in the middle of the night and woke up feeling refreshed for a change.
My plan was to follow what I've read and do an injection every other day until everything is back to normal but by late morning, the throbbing in my right leg was back and I'm now a bit worried.
My original B12 level was 376 back in the middle of August and I started supplementing with 1000ug MethylCB every day on 25 August which helped with the brain fog and mental clarity really quickly. On 11 September I added oral spray MethylCB which cleared my bursitis within a couple of days and everything progressed for a little while. I changed the oral MethylCB to Jarrow sublingual on 9 October as I'd developed a throbbing pain which felt like it was in the bones of my right leg and keeping that company was a side order of pins and needles in my left thigh, both of which would wake me up at 3am and have a party. My thought was that I wasn't absorbing the tablets properly (I had been on PPIs for 25 year but not taken them for 18 months).
My last blood test on 19 Oct showed B12 at 1476 (I asked the lab about discontinuing supplements and they advised I'd need to discontinue for 3-4 weeks before the test - not really a palatable an option for me). By this point the patch on my left thigh was permanently numb and I'd experienced a "ripping" sensation as well as cascades of pins and needles around the area which seemed to be spreading so I was quite surprised by the test result which was when I ordered the injections. I haven't yet had the Active B12, homocysteine or MMA tests (funds are a little limited by thyroid tests and other supplements and timing). I am due to see my GP again on Monday but am not hopeful that he'll take any notice as he wouldn't accept the results of my own Blue Horizon tests and wants to refer me to a neurologist if the results of B12 test he wanted to do come out normal (which they will)
My worry is that every time I change/increase treatment or dosage, everything is fine for a while - it's like I take three steps forward and then one backwards. I know something like this takes time to heal and I may be worrying unnecessarily (in which case please feel free to deliver a slap) but if anyone has any advice or insights, I'd be more than happy to read them.