I do not have a diagnosis of PA, but of primary progressive MS, however I thought I'd try B12, as I am offered no other treatment, and much of my symptoms, and the way it developed also seemed to fit subacute combined degeneration. (Low serum b12, high MCV and mch, symmetrical numbness starting from big toes, moving up my legs, MRI 4 segment diffuse inflammation of spinal cord and hydromelia, in cord, cervical and thoracic, brain clear).I have had no new symptoms for 2 years- started sublingual b12 then and gradually upped my dose to 2 x 5000 tablets daily a year ago.
My feet and hands have been like blocks of ice for several years, way before my diagnosis, but I understand that one of the things PA or other b12 deficiency does is make your blood too big to fit in the small capillaries in your extremities.
So, a month after doing 1000 sub cutaneous injections, (alternate days for 3 weeks, then 1 weekly so far), possibly getting more of it in me as I gradually get better at the jabs, I am much less stiff in arms and legs and for the last couple of days, my hands and feet are generally warm, a couple of times actually hot. It is very hard to be subjective; I was not expecting miracles, but I can't see any other variable to explain this? Even if this is the only change, I am grateful.Am I grasping at straws?