Costantini, Naviaux: chronic fatigue

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Metabolic features of chronic fatigue syndrome.

Naviaux RK, et al.

PNAS 2016

ncbi.nlm.nih.gov/pubmed/275...

Compare essay by Dr. Naviaux with essays by A. Costantini regarding fatigue that occurs in many illnesses.

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a costantini thiamine fatigue.

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From Naviaux: "Metabolomics has several advantages over genomics for the diagnosis of complex chronic disease and for the growing interest in precision medicine (5)."

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From Naviaux: " espite the heterogeneity of triggers, the cellular response to these environmental stressors in patients who developed CFS was homogeneous and statistically robust. These data supported the notion that it is the unified cellular response, and not the specific trigger, that lies at the root of the metabolic features of CFS."

[aspergerian in reply to aspergerian]

From Naviaux: "The decrease in plasma purines in CFS is consistent with decreased synthesis and/or turnover (flux) of ATP and GTP and decreased reserve capacity caused in part by a generalized decrease in the ability to restore high-energy phosphate stores after exertion."

[aspergerian in reply to aspergerian]

From Naviaux: "The metabolic features of CFS and dauer correspond to the same pathways that characterize the acute CDR and metabolic syndrome (50) but are regulated in the opposite direction. For example, cholesterol, phospholipids, and uric acid are often elevated in the acute CDR and metabolic syndrome, but these metabolites were decreased in CFS patients."