St John's Wort (SJW)

[aspergerian]

An intriguing post about St John's Wort (SJW), etc.

The potencies for the uptake inhibition of NA, DA and 5-HT were 30,

7 and 1, respectively. The results indicate that the SJW Ze 117

extract interferes in three ways with the individual uptakes of the

relevant neurotransmitters that are considered to be causal in the

development of depression.

longecity.org/forum/topic/6...

[aspergerian]

Cross reactivities to SJW merit consideration.

Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations.

AAPS J 2009 Dec;11(4):710-27.

ncbi.nlm.nih.gov/pmc/articl...

[isis6361]

You shouldn't be taking this with Parkinson's as it has the potential to block dopamine

[aspergerian]

I have not recommended that a PwP ingest SJW. The concept and findings regarding neurotransmitter reupake inhibitors may be relevant.

For instance, three items. One is a wiki snippet. Two present open access articles.

en.wikipedia.org/wiki/Dopam...

A dopamine reuptake inhibitor (DRI) is a class of drug which acts as

a reuptake inhibitor of the monoamine neurotransmitter dopamine by

blocking the action of the dopamine transporter (DAT). Reuptake

inhibition is achieved when extracellular dopamine not absorbed by

the postsynaptic neuron is blocked from re-entering the presynaptic

neuron. This results in increased extracellular concentrations of

dopamine and increase in dopaminergic neurotransmission.

Monoamine

reuptake inhibitors in Parkinson's disease.

ncbi.nlm.nih.gov/pmc/articl...

The motor manifestations of Parkinson's disease (PD) are secondary

to a dopamine deficiency in the striatum. However, the degenerative

process in PD is not limited to the dopaminergic system and also

affects serotonergic and noradrenergic neurons. Because they can

increase monoamine levels throughout the brain, monoamine reuptake

inhibitors (MAUIs) represent potential therapeutic agents in PD.

However, they are seldom used in clinical practice other than as

antidepressants and wake-promoting agents.

This review article summarises all of the available literature on

use of 50 MAUIs in PD. The compounds are divided according to their

relative potency for each of the monoamine transporters.

Despite wide discrepancy in the methodology of the studies reviewed,

the following conclusions can be drawn: (1) selective serotonin

transporter (SERT), selective noradrenaline transporter (NET), and

dual SERT/NET inhibitors are effective against PD depression; (2)

selective dopamine transporter (DAT) and dual DAT/NET inhibitors

exert an anti-Parkinsonian effect when administered as monotherapy

but do not enhance the anti-Parkinsonian actions of

L-3,4-dihydroxyphenylalanine (L-DOPA); (3) dual DAT/SERT inhibitors

might enhance the anti-Parkinsonian actions of L-DOPA without

worsening dyskinesia; (4) triple DAT/NET/SERT inhibitors might exert

an anti-Parkinsonian action as monotherapy and might enhance the

anti-Parkinsonian effects of L-DOPA, though at the expense of

worsening dyskinesia.

See also.

Natural

polyphenols: Influence on membrane transporters.

Hussain SA, Sulaiman AA, Alhaddad H, Alhadidi Q.

J Intercult Ethnopharmacol 2016 Jan

27;5(1):97-104.

ncbi.nlm.nih.gov/pmc/articl...

"Therefore, the objective of this article is to review the potential

efficacies of polyphenols in modulating the functional integrity of

uptake transporter proteins, including those terminated the effect

of neurotransmitters, and their possible influence in

neuropharmacology."

[bassofspades]

Herbal Prozac. I used to take it for depression / apathy before i went in the hinz protocol. The stuff works good. I was also taking it because i heard it helps to repair nerves n stuff, but i cant recall where i heard that.

[Boyce3600 in reply to bassofspades]

Where do u find herbal prozac ?wonder if there's such a thing as herbal zoloft

[bassofspades in reply to Boyce3600]

Im saying that st john wort is herbal Prozac.

[Boyce3600]

Oh sorry I didnt know that. Glad it helps!