Two areas of PD research overlap: mitochondria and lysosomes (1-4).
Even the MJF Foundation is involved (5). See also: (6-10). Insights
from interactions among mitochondria, lysosomes, and mitophagy may
lead to beneficial therapeutics. Will anything helpful be found
among supplements and nutrients? Don't know, but Costantini's B1
therapy addresses mitochondrial function. Technical citations. More research is needed.
1.
healthunlocked.com/parkinso...
2.
healthunlocked.com/api/redi...
3. Loss of Mitochondrial Function Impairs Lysosomes.
J Biol Chem 2016 May 6;291(19):10263-76.
ncbi.nlm.nih.gov/pubmed/269...
4. Neuronal Mitophagy in Neurodegenerative Diseases.
Front Mol Neurosci 2017 Mar 8;10:64.
ncbi.nlm.nih.gov/pubmed/283...
"Dysfunctional cellular proteolytic systems have been linked
extensively to neurodegenerative diseases (ND) like Alzheimer's
disease (AD), Parkinson's disease (PD), or Huntington's disease
(HD), with autophagic failure being one of the main factors
contributing to neuronal cell death in these diseases."
5. Targeting the Lysosomal Pathway to Ease Mitochondrial Dysfunction
in IPSC-Derived Neurons from People with Parkinson's and GBA
Mutations
MJFF Target Validation, 2016
michaeljfox.org/foundation/...
6. Parkin and PINK1 function in a vesicular trafficking pathway
regulating mitochondrial quality control.
EMBO J 2014 Feb 18;33(4):282-95.
ncbi.nlm.nih.gov/pubmed/244...
7. PINK1/Parkin-Dependent Mitochondrial Surveillance: From
Pleiotropy to Parkinson's Disease.
Front Mol Neurosci 2017 May 1;10:120.
ncbi.nlm.nih.gov/pubmed/285...
8. PINK1, Parkin, and Mitochondrial Quality Control: What can we
Learn about Parkinson's Disease Pathobiology?
J Parkinsons Dis 2017;7(1):13-29.
ncbi.nlm.nih.gov/pubmed/279...
9. Mitochondrial lipids in neurodegeneration.
Cell Tissue Res 2017 Jan;367(1):125-140.
ncbi.nlm.nih.gov/pubmed/274...
10. The ubiquitin signal and autophagy: an orchestrated dance
leading to mitochondrial degradation.
EMBO Rep 2016 Mar;17(3):300-16.
ncbi.nlm.nih.gov/pubmed/268...
11. TMEM175 deficiency impairs lysosomal and mitochondrial function
and increases α-synuclein aggregation.
Proc Natl Acad Sci USA 2017 Feb 28;114(9):2389-2394.
ncbi.nlm.nih.gov/pubmed/281...
12. Lysosomes and α-synuclein form a dangerous duet leading to
neuronal cell death.
Front Neuroanat 2014 Aug 14;8:83.
ncbi.nlm.nih.gov/pubmed/251...
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