This is a summary of every article in Pubmed with a direction connection between magnesium and parkinsion's. Seems like one of the most important nutrients that the general population is supposed to be low on.
magnesium (MG)
==========
magnesium inhibits alpha-synuclein aggregation in PD cells test tube
ncbi.nlm.nih.gov/pubmed/118...
3 times fewer PD cases in Japanese with high magnesium
ncbi.nlm.nih.gov/pubmed/214...
intracellular Mg protection in PD cells test tube
ncbi.nlm.nih.gov/pubmed/263...
magnesium deficient mice are susceptible to developing PD
ncbi.nlm.nih.gov/pubmed/197...
manganese (not magnesium) inhibits Mg ability to catalyze LRRK2-mediated phosphorylation of tau. PD in test tube. Relevant to explaining manganese (not Magnesium) toxicity and a certain familial (gene mutation) cause of PD.
ncbi.nlm.nih.gov/pubmed/261...
low magnesium, phosphorous, and folate associated with PD and loss of smell. More carbs and fewer PUFAs associated with PD. 87 human patients.
ncbi.nlm.nih.gov/pubmed/215...
Mg deficiency causes parkinsoniasm? (Russian paper)
ncbi.nlm.nih.gov/pubmed/185...
Mg concentration of 4.0 mM completely prevented any decrease in the number of dopaminergic neurons due to MPP toxicity in test tube cells. "This is the first report to document a significant and striking effect of Mg for prevention of neurite and neuron pathology, and also amelioration of neurite pathology in a PD model."
ncbi.nlm.nih.gov/pubmed/182...
Mg higher in PD patients' blood, but lower in CSF based on severity and duration of PD
ncbi.nlm.nih.gov/pubmed/167...
Magnesium and PD connection first discovered in 1962. In 28 PD, delirium tremors, and familial tremors, patients not taking PD medication Mg was 50% higher in blood than in normal population than in
ncbi.nlm.nih.gov/pmc/articl...
Only lower Mg caudate nucleus and lower copper in SN were noted in PD patient post mortem brains out of 24 metals tested.
ncbi.nlm.nih.gov/pubmed/276...
Mg protects against Al and Cd toxicity in PD
ncbi.nlm.nih.gov/pubmed/186...
ncbi.nlm.nih.gov/pubmed/147...
"Magnesium deficiency cannot result in neurodegenerative disease." (??)
ncbi.nlm.nih.gov/pubmed/951...
proton pump inhibitors to reduce gastric acid can lead to reduced magnesium and lead to Parkinson's