Fisetin for PD

[zawy]

Here's a single-case study involving Fisetin (found in strawberries, apples, and onions) that improved symptoms:

ncbi.nlm.nih.gov/pubmed/228...

"The basic diet alone failed to prevent decline due to PD. In 2009, the basic diet was enhanced with a good dietary source of both fisetin and hexacosanol. Six months after the patient started the enhanced diet rich in fisetin and hexacosanol, a clinically significant improvement in symptoms was noted; the patient's attending neurologist reported that the clinical presentation of cogwheel rigidity, micrographia, bradykinesia, dystonia, constricted arm swing with gait, hypomimia, and retropulsion appeared to be resolved. "

Someone posted details not in the abstract:

" The patient’s medication dosage in December 2008, before

beginning the complete diet rich in fisetin and hexacosanol,

included 7½ carbidopa/levodopa 25/100 and 1mg

of rasagiline daily. By June 2009, 6 months after starting the

complete diet rich in fisetin and hexacosanol, the patient was

able to reduce the medication dose to 4½ carbidopa/levodopa

25/100 and ½ mg of rasagiline daily, while benefiting

from amelioration of motor symptoms. In October 2011

medication doses were 6 carbidopa/levodopa 25/100 CR and

¼mg of rasagiline, while maintaining the significant improvement

in allCUSS motor movements obtained in 2009.

Then I found where the patient herself posted an update this year:

" I'm the retired dietitian in the article. (My neighbors wanted me to share how my walking, etc, improved so dramatically, thus the published article.) Here's an update. I was doing well until late 2013 when I developed an allergy (characterized by flushing and breathlessness) to strawberries and several other foods. By February 2014 I had to stop consuming strawberries. Many of my symptoms began to worsen. In June 2014 I started taking the Swanson brand of fisetin. To approximate the amount in strawberries I divide the each capsule into six portions, taking one at breakfast and one a dinner. Over several months my symptoms again improved.

" In January 2015 I became intolerant of rasagiline and synthroid, stopping both in February 2015. Without the rasagiline, I have more tremor, etc, but am able to function well. I'm currently taking 6 carbidopa/levodopa 25/100, and one 25/100 CR at 10 PM.

neurotalk.psychcentral.com/...

[Coblrman]

The one thing you have to be cautious about with a single study is according to one research analyst it seems that all PD patients are over prescribed and most will see little change with possibly some improvement with an appropriate cut in medication.

Nevertheless, anything that sounds safe and has possibilities I say "go for it." I just suggest reading up on the proper dosage and any side-effects first.

[Hidden]

Dear zany, I am not yet taking any PD meds except for Mirapex for RLS .....very low dosage. I wud like to give Fisetin a try. Pls adv if you continued with some form of hexacosonal although I don't yet know what that is. I shud have done some research before sending this I guess!

[Beckey]

How much of each food source and how often? I wolf down strawberries by the basket in the summer and apples in the winter and add onion to just about every savory dish I cook. Being by nature a fruit-etarian, I could easily add more of each to my diet!

[Beckey]

Hmm... More about fisetin: alzdiscovery.org/cognitive-...

and a very little bit more about hexacosanol (AKA octacosanol)

emedicinehealth.com/octacos...

[zawy]

It's really strange that web site says hexacosanol might be bad for PD and interact with L-DOPA. There was absolutely nothing the medical literature about this. It appears to me that they are using an automated program for searching the medical literature which then writes the text of their articles. This "study" I've linked to and two positive studies (mice and then rats on the 2 most popular PD-force models in them, each study by the same group) are the only things. So I think their program found these articles and somehow drew the opposite conclusion. It's a waxy acid in stuff like wheat germ and some olive oil and is supposed to help utilize oxygen better. There was only 1 study in people back in 1984 (other than this anecdote). The amount to take to simulate the work in mice and rats would be about 15 pills per day, but the tests were short term, so 5 per day is more reasonable.

I could not find the dose for fisetin, but the amount in the pills seem to be more than enough, and this nutrionist that's taking it is dividing the doses. It's not expensive, so I'll take 1 a day.

Keep in mind this "study" is about a single case.

I already ordered some fisetin from amazon, and will review the amazon comments later to see what people generally believe it is good for. I am interested in it because strawberries and apples (which it is found in) are the two fruits that had the strongest protective effect in men. It would be interesting to found out how this nutritionist came to the conclusion it might help her.

Beckey, maybe your body has sensed you need these and they have already been providing some protection.

[laglag]

FYI: I briefly looked up some info on fisetin & found that a "dose" of strawberries is 37.

[zawy in reply to laglag]

Strawberries are about 15 grams each, and the fisetin in them is 160 ug/g (160 ppm). Pills have 100 mg, which works out to be 41 strawberries, so 37 strawberries seems accurate. This is about a pound and a half of strawberries which costs $3. The 1 pill per day cost $0.50 per day, 6 times cheaper.

[aspergerian]

Protective effects of fisetin and other berry flavonoids in Parkinson's disease.ncbi.nlm.nih.gov/pubmed/287...

[aspergerian]

Protective effects of fisetin and other berry flavonoids in Parkinson's disease.

ncbi.nlm.nih.gov/pubmed/287...