Parkinson's Movement
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Annette Freeman protocol

I ran across a protocol for curing Parkinson's Disease about ten yrs ago . It included antioxidants, enzymes and amino acids. I tried to follow it but gave up and now I am deteriorating rapidly. Has anyone had experience with it or even heard of it before?

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Hi Reneep,

I have not heard of that...but I have a supplement that is based on the latest research. Google TUDCA. There is a prescription form called UDCA, but TUDCA is simply the taurine conjugate. It restores mitochondrial function that is about 80% of the PD problem (usually marketed as liver support). It will start working in less than 10 days. Take 500mg in the morning, 250 at lunch, 250 at evening, and 250 at night...always take with at least some food. Several companies sell it. Not trying to sell anything, just trying to help. It will not cure PD, but basically pause progression. You might have some symptom relief as well, to the extent that dormant cells can be reactivated...however, brain cells that have died are then dead. This is not a cure, but as close as possible. After you try this for 30 days...email me....there is a way to take care of the rest of the remaining problem of PD (A-syn aggregation). ...but first things first...

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Thank you so much, I certainly will!

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I have been looking at TUDCA. It's very expensive at the dosage you are suggesting.

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Tumeric and cumin do similar things.

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Hi 12stargate...that is somewhat true. Tumeric/curcumin does well to act as an alpha synuclein aggregate inhibitor, as well as assist in mitigating neuro-inflammation and oxidation.

Gallic acid however, is known to not only be an alpha synuclein aggregate inhibitor, but also to actually break down the clumping that has already formed. Thus reducing the microglial immune response. Gallic acid is found in many fruits, such as blueberries, grapes, etc. Grape Seed Extract is a great source of it, and is not very expensive. Also, Triphala contains significant quantities of gallic acid.

EGCg is also a good source of a compound that aids in minimizing toxic a-syn aggregation and clumping. Taking all of these together (gallic acid being the most important) would possibly yield a synergistic effect.

The above assists with about 20% of the root cause of PD.

However, 80% of the problem with PD is mitochondrial dysfunction. That is where UDCA (prescription) or TUDCA (supplement) comes into play. TUDCA is simply the taurine conjugate form of UDCA, as UDCA turns into TUDCA when processed by the liver and by the bacteria in the intestines.

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Just started looking at TUDCA as a next possibility to try for my husband with. There is not a lot of information on it for PD. Are you taking it and for how long? Do you notice any changes?

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Hi Answerseeker...

TUDCA is simply the taurine conjugate of UDCA. They act exactly the same way since UDCA is simply converted to TUDCA (and small amounts of GUDCA) when your body processes it.

I started taking UDCA several months ago. My PD has not progressed since then and I no longer have PD symptoms. I was on an MOA-B inhibitor, but I am not any longer. I had to start taking TUDCA a couple months ago when Costa Rica ran out of UDCA. Just as the science suggests, I have found that it works in the same way.

Here is all of the journal articles on every supplement and why they work:

reverseyoungparkinsons.com/...

My recommendation (for whatever that is worth LOL) is to buy two bottles of TUDCA. Most have seen benefits in 10 days or less. If benefits are seen, that means that cells that were dormant have been reactivated to produce dopamine again, as the result of mitochondrial restoration....this means that your brain cells are no longer starving to death (thus slowing down PD progression).

brain.oxfordjournals.org/co...

However, brain cells that have died...well...they are dead.

Thus, the degree of symptom relief is limited to the degree of restorable dormant neurons in the substantia nigra. The brain cells go dormant for a period of time before the mitochondria decide to push the self destruct button for a non functioning cell (to preserve resources for surrounding)

This will NOT cure PD. But, it has the potential of stopping or slowing down PD progression...especially if one decides to not only restore dysfunctional mitochondria, but also tackle the a-syn aggregation.

I hope that helps some...

jon

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I currently take 500mg of TUDCA in the morning, 250 at lunch, 250 at dinner, and 250 at bed.

Others that have been doing this longer than I have recommend starting at a half dose of the above for the first three days. Some experience some digestive responses...such as heart burn (TUDCA is a bile acid salt) or diarrhea.

The person I know who has been doing his the longest so far is 15 months with no progression...his is 70+ years old and has had PD for a while. He still has to take L-DOPA and was not able to successfully reduce the Sinemet dosage, but he did have symptom regression, and no more symptom progression for over a year...which was signifiant to him, because he was progressing daily.

So far, 100% of people that have tried it have had a form of benefit. It is still WAY too early to know for certain to what degree progression has ceased or slowed. But, it is easy to tell that it has certainly slowed at minimum.

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Thanks, Jon. I just placed my order for 2 bottles. I really appreciate the good information you have shared. My husband is 78, has had PD symptoms for 11 1/2+ years and is still determined to keep working. He has never taken PD meds but has been taking LDN 4.5 mg and recently Synthroid 37.5 mg. I am a nutritionist and I have him on many of the supplements on the reverseyoungparkionson.com website plus. (I assume you are the one that put it up.) Thank you!!!!!

Most of all what helps is when he manages to get 7-8 hours sleep at night and gets more than his minimum daily exercise in. We also laugh a lot and sing and dance at every opportunity. Definitely helps quality of life!!! (L.O.L.)

I will post what response he sees after a month. All the best!

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That is awesome...wishing for the best results!

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Jon,

My husband has been experiencing a bit of reflux about once a day which is resolved with a homeopathic we have for reflux. He is taking 250 mg. 2X/day for 4 days. (Started at just 1 the first day. He did have some digestive issues with Coconut oil and MCT when we first started them because I introduced too much too quickly so I am being cautious and going slow. His Bilirubin runs high when not on Milk Thistle and he has a family history of Gal Bladder issues .

I am keeping him at the lower dose until I see this resolve. From the feedback that you have received does this usually go away and is there variation as to how long that takes? He also had 2 episodes of more extreme urgency than is customary. Has this been reported? (It had gotten somewhat better with the additional of more Pumpkin seed oil and it might be that he skipped some doses of this as well.) Realize your knowledge of others experience is somewhat limited but it is certainly more extensive than mine.

Thanks for any feedback you can give!

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Yes-I have. Annette started it years ago early on in the illness. To my knowledge she is still alive & well. I even tried it for a while and as you say-it is difficult to follow. All regimens are. After all, we are human beings, not robots! My answer after nearly 20 years with this thing has been DBS Surgery, mucuna pruriens, and some supplements recommended by John Gray (Women are from Venus and Men are from Mars author). Relax some -the cure is coming--see Michael J. Fox Research on his website. Most importantly -be well and exercise All You Can!!!!!

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I have found that when my off periods are prolonged exercise is the only thing that will help!

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Thank God for my local rehab pool & hot tub! I also use Low Dose Naltrexone nightly to slow progression (see book HONEST MEDICINE).

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Hi Reneep. I know of nothing that can cure Pd. There IS NOTHING! That is the bad news. The GOOD NEWS is that there is something you can do to take back control of many of your movements. It is FAST WALKING. When you walk fast you produce a chemical in the brain that repairs the damaged brain cells. This chemical (GDNF) is manufactured by a drug company and has to be pumped into the damaged area of the brain through a catheter. Therein lies the problem.

My argument is, "Why have an expensive operation and continuous treatment to place this chemical where it is needed, if you can get it there naturally by doing regular fast walking?

I would have to write screeds of info here about it all, but it is all available, free of charge, on my website - reverseparkinsons.net. Go to the website and read all about it.

I was diagnosed with Pd in 1992, when I had to give up my job and then all i had to do was to look forward to going downhill until I would have become bedridden. I started doing fast walking in 1994 and by 2002 I came off my medication and no longer needed to see my neurologist as nobody would ever have known I still have Pd.

It was not just the walking but the medication, the stress management, the attitude adjustment and doing brain exercises. None of which costs anything to do! Look it all up on my website!

Good luck!

John Pepper

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I am a believer in exercise and I will check out your website!

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Please post your e-mmail address so i can reply.

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sonias@juno.com

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Dear Annette: I have heard about amino acids being great for PD.

if I find the title of the book, I will let you know.

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I have Parkinson & have never heard of that. I am starting to take coconut virgin oil. According to a man on site, He has been taking it & said it really helped Him a lot.We got it at Wal Mart.

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UDCA failed in controlling liver histology, or symptoms, in a dose of 13–15 mg/kg/day [191,192]. In a higher dose of 28–30 mg/kg/day, UDCA resulted in more than double fold increase in patient deaths, and need for liver transplantation. There is an exceptionally narrow difference between recommended dose and detrimental dose of UDCA in primary sclerosing cholangitis [13,26]

Meta-analyses of four randomized clinical trials randomizing 279 patients could not find significant differences regarding mortality or improvement in liver function tests observed after treatment with UDCA. Data on the radiological and histological responses were too scant to draw any definite conclusions [208]. High dose UDCA failed to improve the overall histology in 185 patients with NASH in comparison with placebo [209].

UDCA, is of unproven effectiveness in cholestasis, acute or chronic liver disease, colorectal carcinoma, and has specific molecular toxicity. It freezes regeneration and induces cellular hibernation. No case control double blind trial has demonstrated its true curative effects in any liver disease.

Despite high hopes and tremendous expenditure, space and chance for UDCA to effect, it does not go beyond “cellular freezing”, and arrest of cellular regeneration.

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I am? sooo confused. What is UDCA

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bear bile?

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Hi Annette. A friend emailed it to me and I'm happy to pass it on but it is quite lengthy. It might be easier to email it to you directly. Would a Word attachment work? I can also put it in the body of the email. You can email me directly at rrosenlum@gmail.com.

Anyone else?

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Ok, thank you!

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