I know it does but last night was a prime example. After a pretty good day got a phone call to say that my adult son, who has kidney problems, had developed a severe infection and needed to go to hospital. He gets these infections but all hell broke loose with my tremors. Had to go down with my husband to look after his daughter of 3. Took an extra Stalevo which made no difference so just had to get on with it. They kept him in hospital overnight. I am no better this morning..Just waiting for my grandaughter to arrive.