Does PERT even work?

[Ozette]

Is there anyone who takes replacement enzymes successfully and what that might look like or feel like? I started Creon 3600 last December and still have much of the same symptoms as before. It's very discouraging as it can be quite restrictive. I can't plan anything for early in the day, I feel hungry nearly all the time and never sure about what or what quantity to eat and I'm often very tired.

[Epiguy]

Well I’ve been taking Creon 36,000 since June of this year (2024). I eat smaller meals and generally take 2 with breakfast and 2 with dinner. I don’t always eat lunch and depending on size I will take 1 or 2 if I do eat lunch. As far as snacks go it will depend on size and type of food. Generally I take 6 or 7 pills each day. Now it took a few weeks but I generally feel better. My bowels are fine but I still get occasional bloating . I always feel better when exercising and/or light jogging. A big problem with Creon is it’s price. When my pills run out I plan to switch to Zenpep (whatever the hell that is…). Anyway, the Creon will work eventually. Limit the size of your meals and eat frequently and healthy and take more if needed. Good luck!