Pain Concern
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Duloxetine for Postherpetic Neuralgia


I'm 30year old woman suffering with postherpetic neuralgia following shingles, in my shoulder, neck and arm for nearly 2 years. Been having Qutensa patches every 12 weeks for one year ish with limited effect but seems to be building slowly. I take Tramadol 100mg x 4 daily plus paracetamol, effect also now quite limited.

I've just been offered duloxetine and wondered how others had found it, especially for nerve pain. I have related depression as many with pain do so guess the anti depressant effect will be a bonus! have tried amitrip, gabapentin and pregab previously all with no real effect, amitrip was the worse for negative side effect. Also use lidocaine patches which can take the edge off.

I have also been advised by my consultant to look into Botox but understand this would have to be done privately - has anyone tried with success ? No idea what this would cost. Have been unable work for 18 months so money tight but will do what I can go get well and back to work.

Any advice or experiences will be of interest please, thanks x

4 Replies

I should also add I've already had a botched dorsal root ganglion block which actually accelerated my pain, aside from gaining a punctured lung in the process - never again!


Pain clinics do Botox or botulinum injections on the NHS, it's not a cosmetic procedure so should not cost anything.

I hope you get relief soon,

My mum took that antidepressant for a few years and it did help enough along with pain killer to get her moving more.


Hi thanks for this - I was told at my local pain clinic (Bristol) it was not available on NHS, do you think it depends where you are?


Hi there

My pain is very different to yours I have found pregabalin extremely effective for my pain it enabled me to reduce my OxyContin m/r from 50mg twice a day to 20mg twice a day that was before side effect was on 300mg twice a day now on pregabalin 150mg am and225mg pm . The duloxetine was added and now on 60mg it dose help with fibromyalgia pain but I feel quite flat on it as regards to antidepressant . My GP said he would nt try it if the pregabalin did nt work but it been shown to work for diabetic neuropathy . The choice is yours think he checked my bp regularly and built dose from 30mg to 60mg to 120mg then down again to see where was best I think you have a good chance of it working for years I took it at night until last month when in hospital I met a lady who was on duloxetine and she said pharmacy advice do her to take it am . I have nt been sleeping at about 11pm for years I wake up it's been hell within a week I am awake all day and sleep fairly well at night amazing for me good luck whatever you decide . I have had Botox to into pancreatic nerve area think did help but it invasive where as tablet is nt . Good luck love hope something helps you love squeak xx


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