Fatigue from Avastin and Olaparib

[Cancer_girl]

Hi lovely ladies!

Does anyone have any experience of fatigue on Avastin and Olaparib?

Following a 4b diagnosis last year, 6 rounds of Carbo/Taxol and debulking surgery, I am currently very lucky to have NED.

I started Olaparib and Avastin in February as maintenance and the fatigue has got progressively worse. Also suffering from muscle and joint aches. I only have a couple of rounds of Avastin left so aim to finish that as planned and then see how I am doing. My oncologist thinks it is probably the Olaparib causing the fatigue and thr Avastin the muscle/joint aches. Only option to help seems to be to reduce the dose which I would prefer to avoid for obvious reason.

I am very lucky to be I such a good position given where I started, so I feel somewhat guilty that I am struggling more now physically and emotionally than at any other point in this journey. Some hope that the fatigue might get better would help...

Thanks all!

[DianaPrince_]

For me it was the Olaparib. I was hobbling a bit towards the end of my two-year maintenance treatment. Joints just ached. Especially my ankles. Once I got going it was ok. I felt like was rusting.

I also had to have a dose reduction. Had thrombocytopenia (low platelet count). And needed a blood transfusion.

the fatigue was just there all the time, and got very bad during the low platelet bit. Nowhere near as bad as with chemo though. Lifted pretty quickly once I finished.

Oh and if I moved around too much after taking my dose I'd vomit.

I've just started Avastin, one infusion down, I'm noticing some stiffness, a light rusting.

Have a blood test, check your platelets.