Elevated C125

[Tajinder1]

Hello all,

I recently had a test that showed elevated C125 in the womb area. I believe it is raised to 76. I was told that this could be an indicator of cancer being present. We still need to do further tests.

As this is all new to me, I was wondering if anyone might be able to shed some light on this?

Thank you in advance.

[Dolphinseasshore]

Hello, my consultant told me that it is an indicator that things need looking into, nothing more. Have all the tests & the very best of luck x

[Tajinder1 in reply to Dolphinseasshore]

Thank you. That puts my mind at rest. Best of luck to you too.

[SopSinger]

CA125 is a cancer antigen (protein) that is secreted in the blood by some cancer cells, especially ovarian cancer. It can also be triggered by inflammation anywhere in the body (even a cold) so is insufficient to make a diagnosis. 76 is a relatively small elevation (I've heard of readings in five digits) but the NICE guidelines say that if it is over 35, further investigations should be done. Your doctor is doing the right thing for getting further tests done. You should have a transvaginal ultrasound (to visualise the ovaries) and if that shows anything suspicious it should be followed up by a CT and/or MRI scan. There's a great resource at fwc2022stg.wpengine.com/wp-...

[Tajinder1 in reply to SopSinger]

Thank you so much. That makes things a lot clearer.

[Leniko]

Certainly needs looking into, further tests. Keep in mind that inflammation in other areas of the body can effect the CA125. Best of luck to you.

[Tajinder1 in reply to Leniko]

Thank you. That’s what I’m hoping. I do suffer from a number of other ailments and take HRT.

[marmay88o]

Hi Tajinder,

Unfortunately, my CA, 125, went up from an average of 11 to 59. I’m very concerned. They did CAT scan and PET scan and nothing has showed. It could be inflammation or infection.

[Tajinder1 in reply to marmay88o]

I understand your concern. Im hoping it’s inflammation or the fact that I’m taking HRT. Im so glad your results came back clear.

[marmay88o in reply to Tajinder1]

Good morning, what is HRT?

[OvacomeSupport Partner My Ovacome Team in reply to marmay88o]

Good afternoon marmay88o

Thank you for your question. HRT stands for Hormone Replacement Therapy. The NHS explain that 'HRT is a treatment used to help menopause symptoms. It replaces the hormones oestrogen and progesterone' which reduce with menopause. If you would like to learn more, the NHS have further information here on their website: nhs.uk/medicines/hormone-re... .

In addition, Ovacome have an information resource all about surgical menopause which is available through this link: ovacome.org.uk/surgical-men... . This includes a section all about HRT.

I hope this information is helpful. If there's any further information we can provide or anything we may be able to support with, please don't hesitate to get in touch with us. You can reply directly through this forum, email [e-mail] or call our Freephone support line on 0800 008 7054. We're here Monday - Friday, 10am - 5pm.

Best wishes

Annie - Ovacome Support

[Frannyfrank52]

Make sure on test is a cat or pet scan. To be sure Ca125 in not 100# reliable but a good indicator of how your body reacts to treatment

[Tajinder1 in reply to Frannyfrank52]

Thank you. That’s very useful to know.

[Lizchips]

Normal ca125 is 0-30. It is only an indicator. Don't panic . Other things can raise this. Best wishes, Liz

[Tajinder1 in reply to Lizchips]

Thank you Liz. Common sense tells me it could be a number of things, but until I have the tests, I can’t help worrying. But I do understand your point.