Is there a relationship between platinum sensitivity and BRCA/ HRD status?

[Donnie21]

Hi all,

Is anyone aware of publications (or otherwise) on the relationship between platinum sensitivity and genetic status in ovarian cancer? Put another way, can you infer anything about likely PARP efficacy as maintenance treatment from response to platinum chemo during first line treatment?

Thanks so much and best wishes to all.

D

[Morini]

My understanding (not 100% sure) is PARPS can be most effective with BRACA and/or HRD positive but that's not to say they aren't if you are not. Interesting question about platinum sensitivity and PARPS.

I wonder whether the Ovacome team are best placed to clarify this? May be call the Helpline?x

[Donnie21 in reply to Morini]

Thanks for your reply Morini and yes I gather you are correct in saying BRCA and HRD are associated with improved PARP efficacy. Hope you are getting on well.

[Jayniiee]

Hi Donnie, I'm afraid i can't provide you with any links for research, only the benefit of my oncologist's experience. I am brca negative and my HRD status couldn't be obtained due to sample contamination, hence the decision for me to go on parp inhibitors was a bit of guess work. My oncologist thought it wise for me to take them as she thought it likely that i was hrd positive because i responded so well to chemo (carbo/platin). I went from being inoperable to having a complete pathological response to chemo after 5 cycles. I am guessing then that positive hrd status can be inferred from sensitivity. I hope another of the lovely ladies on here will be able to provide you with links. I'd be interested to read them too. Best wishes

[Donnie21 in reply to Jayniiee]

Hi Jayniiee,

Thanks for your reply and info contained therein. Interesting your oncologist postulated being HRD positive given your amazing response to chemo - congrats! It would make sense and there are some comments in the literature substantiating this - pg 3 para 1 cancertreatmentreviews.com/... refers to ‘clinical hallmarks of BRCA mutated OC include platinum chemotherapy sensitivity….’

Thanks again and best wishes

[Caleda4 in reply to Donnie21]

This is all very interesting,as I am brca negative,but still carbo sensitive,and nearly finished 3rd line chemo carbo/caelyx. I had a parp after carbo/gemzar which was Rubraca, which worked to a degree for approx 15months,after which CA125 was rising. I have mentioned HRD to my Oncologist,but was told they do not generally test for this. Now I am thinking did he think the same because I am still carbo sensitive. Thank you for posting.

[Donnie21 in reply to Caleda4]

Thanks for your input Caleda, interesting to know and hope you have gotten on alright with the carbo/caelyx. Best wishes.

[Jayniiee in reply to Donnie21]

Thank you for the link, Donnie that's really useful x sending you best wishes to keep well xx

[Donnie21 in reply to Jayniiee]

No worries. Another paper that deals with the topic in a bit more detail and concludes there is a high correlation between platinum sensitivity and PARP inhibitor response but it isnt guaranteed - ncbi.nlm.nih.gov/pmc/articl...

[Jayniiee in reply to Donnie21]

Thank you xx

[organicinna]

I dono but am BRACA negative and my first line Carbo Platin wasnt effective and Niraparib did not worked they said. I had 6 rounds of Carbo Platin, then Niraparib just for 3-4 month when they found new little things . I personally think some microscopic cells was left after the op, so it grows again....Now am on Caelyx 6 rounds ,nearly finished and so far it shows am responding to that...

[Donnie21 in reply to organicinna]

Thanks for your feedback and glad you are responding to the Caelyx. All the best

[delia2]

Hi. I have seen a number of statements in the literature that BRCA mutations improve platinum sensitivity, but I can’t tell you where. I have a somatic BRCA 1 mutation as well as a germline PALB2 which is related to BRCA 2. I know you have to be platinum sensitive to go on Olaparib. However I had only a partial response to chemo for first recurrence, carbo caelyx. But Olaparib brought me to ned. I have also seen speculation that if a PARP stops working for you then you have become platinum resistant. But I think that’s unproven.

[Donnie21]

Hi Delia,

Thanks for confirming that and sharing your experience. Hurrah for Olaparib! I have come across similar comments about PARPs no longer working and platinum resistance.

Best wishes