Carbo/caelyx not working

[Comedy123]

Hello friends, I have first reoccurence after 6 months. I had 3 treatments of carbo/caelyx. It didn't work. CT showed progression of disease. Its in my leftover omentum. I feel bloated. Oncologist is going to start me onGemcitabine&Avastin I am really worried & getting anxiety.Did anybody have same experience? Please let me know. Thanks

Harp

[Lyndy]

I haven’t had this experience Harp but I am a great fan of getting a second opinion/ maybe looking at a trial. You have nothing to lose and you might discover another option by going down this route, or you might be reassured that your team have offered the best treatment. Sending you a big hug because this disease is tough mentally as well as physically xx

[delia2]

Hi Harp. I agree with Lyndy. It’s a good time to look at trials— or possibly surgery if it’s only in one location. I know it’s worrying but don’t despair. Sending hugs.

[Comedy123 in reply to delia2]

Thanks Lyndy&Delia. My Dr said surgery is not possible at this time. Harp

[Tillymint61 in reply to Comedy123]

Did you ask the reason why not more surgery? No need to share why, but that's where a second opinion may come in useful for yo. If it supports your teams thoughts then you at least have confidence inthem being on the same page. However another oncologist may believe it is an option . Wishing you well with your treatment whatever form it takes. Xxx

[Gartenfee]

Good morning Comedy. This ist my first post. I'm writing from Germany. My first diagnosis was in 5/2019. I was inoperabel. Instead I got Carboplatin/Gemcitabine followed by Olaparib. in January 2021 I started again with the same Combination Wirth Avastin. Since June I get Avastin alone. I can manage without severe sideeffects, until yet I even did not loose my hair. Last week CT showed stable disease, although my tumormarker are higher than at the beginning of the new treatment. I Wish you good Luck Cheers and big hugs from Germany

[Comedy123 in reply to Gartenfee]

Hi thanks for replying. Did u get vitamin C.through IV during your treatment?Thanks

[Gartenfee in reply to Comedy123]

No the only supplements are vitam D once a week and daily Multivitamin intake

[fendweller]

So sorry to hear this , hopefully an B will work for you .I fear I will be in the same place as you , I've just started carbo/caelyx ,4th line , only had one infusion so far but just have a feeling it's not doing it's job , I too am bloated and uncomfortable . Be strong ,there's options out there for you.

Sending love and wishing you well .

Cheryl x

[rosebine in reply to fendweller]

Caelyx apparently doesnt kick in until about 3 infusions so dont dismiss it yet.Best wishes

[Tillymint61 in reply to fendweller]

I went onto 2nd line carbo on it's own and 1st treatment was harsh with all the symptoms I had made much worse. However the next one with a few tweaks to anti sickness and laxatives and going very plain light regular food for 3 -4 days and drinking more than I felt possible with the bloating the 2nd and 3rd treatments it became manageable. It may be different as I haven't been on a combination yet. But I just had a scan showing slight reductions in all areas still 3 more leading up to Christmas so don't despair you will get the results of the effectiveness which I hope you. It spurred me on to getting back a little positivity and making the horrible treatment tolerable. Sending gentle hugs. Xx

[Comedy123 in reply to fendweller]

Hi, My oncologist said surgery is not safe at present.

[SUE7777]

Hi Harp, I was on carbo/caelyx and i didn't work so I am now on weekly Taxol and hoping to get on prompt trial if it works which it seems to. All the best Sue xx

[Gemmyw]

I had weekly taxol plus Avastin after caelyx didn't work for me. The weekly taxol left me, overall, stable. I'm currently on Gemcitabine as a single agent and am just about to finish that. I think it's radio and/or oral chemo (cyclophosphamide) for me next xxxx

[Ruebacelle]

My 3rd and 4th lines didn't work. Avastin worked for me good luck from paris

[Comedy123]

Thanks everyone for replying. Wish everybody good luck. I hope new treatment will work for me.

[Nus38]

Wishing you well Harp. I have no experience of reoccurrence just finished my first line treatment in April 2021. I have my six monthly CT scan tomorrow...feeling anxious. I hope you can change to a better treatment plan that will shrink the disease into remission.

Love Nus x

[Sherrym]

Caelyx is another option I believe, then if results are good, PARPS.

Much much luck

[rosebine in reply to Sherrym]

OP thinks Caelyx hasnt worked so far

[Sherrym in reply to rosebine]

I think treatment is tailored to individual & is cumulative.. u cd speak to a specialist in the field -I speak to Professor Jon Lederman at LOC. Good luck