Olaparib

[1032]

Is Niraparib the same as Olaparib (Lynparza) one is a brand name. This is an AstraZeneca made drug???

I am on Olaparib. It sounds very much the same as my blood count dropped all the time. I’ve been on it since the end October 2020.

[Sashay2020]

In the states, Zejula is the brand name for Niraparib. It is also a parp inhibitor, but different from Olaparib.

Best wishes from Louisiana,

Sashay

[1032 in reply to Sashay2020]

Thanks and the best from Queensland Australia

[delia2]

Hi. As Sashay said they are both PARP inhibitors but have some differences. There are three PARPs used for ovarian cancer: Olaparib (Lynparza), Niraparib (Zejula), and rucaparib (Rubraca). I believe in the UK Olaparib is used for BRCA positive people and the other two for non BRCA people. They have similar mechanisms but different dosages.

[1032 in reply to delia2]

Thank you.

[Numi in reply to delia2]

Niraparib is now used for non BRCA ladies in the England & Wales, but but was originally used only for BRCA positive as that's the group it's proved very effective for. I have the BRCA2 mutation and I've been on Niraparib since before it was licenced in the UK, as part of the Expanded Access Program which is the stage after clinical trials.

[1032 in reply to Numi]

I was tested for the mutant gene but didn’t have it. Australia put it on their health PBS list, affordable list, November 1.Oncologist appt. yesterday and bloods were 107 and CA125 27. No blood transfusion, Yea!