Octave trial

[govanhill]

Saw oncologist yesterday and we discussed the Octave trial which is a study of enadenotucirev. Wondered if anyone has taken part Thanks Morag

[Lindaura]

This looks very promising. I hope you are accepted in the trial:

In Jan 2015 the European Medicines Agency's (EMA) Committee for Orphan Medical Products (COMP) gave a positive review of enadenotucirev to treat platinum-resistant ovarian cancer.[3]

Clinical trialsEdit

As of December 2015 Two phase 1 trials have been registered:[4] EVOLVE[5] and OCTAVE (in ovarian cancer).[6]

In 2014, positive results from EVOLVE were reported.[2]

OCTAVE started phase 1b in March 2016[7] and is due to complete around March 2017.[6]

The Study of Pembrolizumab In Combination with Enadenotucirev (SPICE) study (not yet on clinicaltrials.gov) will assess if enadenotucirev can reverse resistance to checkpoint inhibitors for various tumour types, including metastatic colorectal cancer.[1]

Best wishes,

Laura

[govanhill in reply to Lindaura]

Thankyou. Hope I am accepted too