Knee Fractures

[Brightside2]

I have recently been diagnosed with fragility fractures in my knees. My Denosumab injections were stopped in January. It may be a coincidence but has this happened to anyone else??

[jaqre]

Hi Brightside2,

I believe Denosumab is the same as Prolia, I have read that it is recommended that you should not stop Prolia cold turkey but need to get on a bisphosphonate afterwards and then be weaned off. If you don't do it this way atypical fractures may result. Please check with your doctor but if they aren't sure get a second opinion from a doctor who works with a lot of osteoporosis cases (endocronologists, etc.). There is a lot of research on Prolia (denosumab) and the proper way to wean off of it. Best wishes!!

[Mark_ABH in reply to jaqre]

This is correct. Here is some basic information on denosumab (aka Prolia) from the American Bone Health webpage on FDA-approved treatments for osteoporosis:

americanbonehealth.org/fda-...

Denosumab is a monoclonal antibody for the treatment of postmenopausal osteoporosis and is given by injection every six months. Prolia works by decreasing the activity of osteoclasts at the molecular level, helping the bone-building cells increase bone mass. Prolia is recommended for women with osteoporosis and high fracture risk, which includes patients who have had an osteoporotic fracture, have several risk factors, or have not responded to other treatments.

Brand name is Prolia®.

Side effects may include back and muscle pain, pain in the extremities, elevation of lipids in the blood, and bladder infection.

Postmenopausal women taking denosumab should not discontinue it without beginning bisphosphonate or other medicine in order to prevent rebound bone turnover and to prevent rapid decrease in bone mineral density and increase in fracture risk.

[Brightside2 in reply to Mark_ABH]

Thank you for this information Mark.

[Brightside2 in reply to jaqre]

Thank you for your help.