Some advice needed please. I started my medication for RA five weeks ago now, MTX and hydroxy, for the first 4 weeks I never really experienced any side affects at all but I also have not experienced any improvement either. However the last week I have felt quite unwell, usual symptoms of RA, with a few extras thrown in, headaches, sickness and neck pain. I have very little energy left now and my question is, should I contact my nurse and tell her or do I just ride it out until I see her on the 19th June? I'm back to work on Monday after the half term break and feel dreadful.