I had to stop the MTX for a while due to high ALT readings. I took 15mg last night and woke up this morning with that familiar MTX feeling, just like a hangover. Headache, tired, feeling yuk, but no alcohol has passed my lips since I had a glass of wine on Friday night. I had quite forgotten that was how the MTX used to make me feel until I got accustomed to it. At least this time I know that eventually this feeling will pass. Fingers crossed the ALT stays low too.