My ESR is consistently about 40 and my CRP is around 57.
I have generalised joint pain and acute fatigue.
I have recently come across studies to do with raised CRP and associated risk of heart attacks. Therefore my question/qestions are around this.
How important in the grand scheme of things is it to reduce CRP levels? Are the risks of Biologics less definate than the risk from uncontrolled body inflamation? What exactly is the statistical risk from uncontrolled body inflamation? eg Heart /cancer/joint damage etc.
Presumably NICE thinks early intervention is a positive thing so or they would not have approved these drugs? Is the prescribing process for Biologics well rationalised? What about those studies which say that CRP and ESR are random results for People with RA- that is people with active disease can have low levels of CRP and ESR and people with minmal Disease activity can have elevated levels! ?
How do we make individual Risk assessments for ourselves? What are the main criteria we would need to involved in drawing up our own risk assessemnt and saying YES to Biologics? High ESR CRP? How much joint involvement?
MY hospital say my disease is aggressive? How do they know? what is the Science behind that statement ? I dont disagree I just dont understand the full rationale for what makes it wise to give Biologics?
I am very mindful of the opinions of some of the Patient experts on here who have questioned whether early intervention with Biologics is always a good thing? Why do others feel like that?
Thanks for any contributions and links !!! ( I still cant insert links to things Ive read so I can include them in my bloggs !- Doh !)