methotrexate change

[trevorlloyd1351]

Started Methotrexate 20/12 with Prednisolone injection as well to deal with immediateflare/s.

In 2025 I have 6 flares of which 3 in the last week of M,arch. I conclude MTX is not for me and a change is needed.

Any views

[Leics]

Hi it’s a shame you feel that methotrexate is no longer working for you which can happen sometimes. You probably need to have a word with your rheumy team as they may wish to tweak the dose or perhaps add another DMARD to prop it up. Unfortunately this is a common occurrence so don’t give up on methotrexate yet get advice and support from your rheumy team I’m sure they should help you out. Good luck I hope things stabilise for you again soon but reach out to your docs sooner rather than later.

[Jfw24]

I found that methotrexate on its own is not sufficient, they normally add an extra dmard to help

[oldtimer2]

It's more likely that your rheumy team will suggest adding in another of the DMARDs unless you are also having unacceptable side effects, as a combination of DMARDs is often successful in controlling the inflammation.

Have a look at the treatment pages on the NRAS website so that you are prepared for your consultation. nras.org.uk/information-sup...

[trevorlloyd1351 in reply to oldtimer2]

Thanks Old timer, had my consultation today. Outcome is the consultant said, Methotrexate fine, so no change. The fact I am having 3 flares a week seemingly not due to RA. We will see! Thanks for the advice , I'll put it on the back burner.