Prednisalone

[Alice70]

Rheaumatolgist trying me on different meds for example hydroxychloroquine now sulfasalazine both making me sick and upset stomache ,I believe it is not them and that it is the prednisalone that is doing it ,I've asked my gp could I try prednisalone gastric resistant his answer was that they don't work as well as the normal prednisalone, I would like to know if anyone else is taking the gastro resistant preds and are they working for them thank you

[Amnesiac3637]

I’ve been on gastro-resistant prednisolone tabs for over 30 years. Due to having stomach and duodenal ulcers from Indomethacin (which is no longer prescribed) my stomach need protecting against any irritants. Uncoated prednisolone is an irritant and therefore why I’ve not been prescribed those.

The coated tabs work fine for me and my rheumatologist has never said otherwise though of course different docs have different opinions.

[Alice70 in reply to Amnesiac3637]

I have rang rheaumatoligy today they are going to ask specialist if I can try them thank you

[Runrig01]

Your gp is correct, the same dose of enteric coated won’t peak as high in the blood. I have adrenal insufficiency and on steroids for life, without them I would die. However I’m not allowed to be given coated tablets for the reason I mentioned. It also takes around 5hrs to reach its peak as opposed to the 2hrs for uncoated. Do you take them after breakfast, and are you on a ppi? Here’s a graph that shows the difference in the 2 tablets.

Prednisolone comparison

[helenlw7 in reply to Runrig01]

I also have adrenal insufficiency and am on steroids for life. My gp doesn’t prescribe the coated steroids. I also take lansoprazole to help prortect my stomach

[Alice70 in reply to helenlw7]

I take lansoprazole 30mgs first thing in morning ,but still by night time my stomache in bits

[helenlw7 in reply to Alice70]

I have 30mg in the morning too and it lasts all day. My husband takes 15mg in the morning and 15mg at tea time.

[Runrig01 in reply to helenlw7]

Over the years I’ve had Omeprazole and lansoprazole as a ppi. Unfortunately I have fused ribs, with no chest expansion, so have lung damage. I have several issues, one being micro aspiration, so my respiratory specialist changed me to Pantoprazole, which is stronger. I also have to take gaviscon advance at night to stop contents leaving the stomach.

Sorry to hear you also have AI, it’s frustrating having to think ahead for what your doing, and whether you need to adjust your dose, and even when you do it’s often not enough 🤗

[Alice70 in reply to Runrig01]

Thank you for the above graph ,yes I take lansoprazole first thing in moring 30mg by night time my stomache burning feeling sick