Sulfasalazine causing me to pee lots

[Charlongo79]

So I’ve been on SF since November but completely lost my sense of taste at Christmas so stopped it. Taste has come back since, however since I restarted it I’m finding it’s making have to pee about double the amount usually do. I was taking 1g am and 1g in the evening but was up and down all night so asked if I could change this. I’m now taking 1g am and 1g at lunchtime and I’m having to pee a lot all afternoon which I suppose is better than all night.

My bloods regarding kidney function is all fine.

When I asked the rheumatology nurses they said they hadn’t heard of having to urinate more as a side effect. They also said they haven’t heard about loss of taste as a side effect either. (And no I didn’t have COVID!). It definitely affects my tongue, I get a numb sort of scraped feeling on my tongue and sore lumps.

Has anyone else noticed it making you pee more?

[KittyJ]

I didn’t pee more on it but are you drinking quite a bit when you take them? That on top of regular drinks might be what’s making you pre more, I know it does when I have to take lots of water with certain meds especially big tablets.

[Charlongo79 in reply to KittyJ]

I’m not really drinking more than before as I drink a lot anyway due to other health issues.

[Fra22-57]

never related to having to urinate more with sulfasalazine but this could be my answer too

[Jojoboz]

Hi there, I have had periods of needing to pee more and with everything started worrying I had diabetes! I was told that Sulfasalazine can increase potassium in your blood and so its important to reduce salt intake and rehydrate. As salt dehydrates you and its hard to tell if you are hydrated with the "orange wee" these tablets cause. If you can cut out as much salt as you can and drink plenty of water. I find 2 or 3 pints of water in a day helps a lot. This really helps and when I am on a "wee fest" its usually because I have had too much coffee and not enough water. I hope this helps. Good luck!

[Jackie1947]

Been on it for 18 years and had nothing like you're saying .Only time I've peed more is if I've had a UTI .