methotrexate injection

[Pepperpot22]

Diagnosed last October, I’ve been on methotrexate since beg of January, then sulfasalazine added in 2 months ago. Pain and inflammation levels still high, so RA nurse is going to switch me to methotrexate injections. Has anyone found it to make a big difference? I’m hoping for some improvement 🤞

[Boxerlady]

I found that going on to injections did help me; more goes into your system so you get a higher dose but hopefully without increased side effects. I was on 15mg tablets ( along with Hydroxychloroquin) and was put onto 20mg by injection. Did try 25mg but it didn't help more and the side effects increased so dropped back to 20 mg. That, in combination with Sulphasalzine, definitely helped me so hope that it works for you 🍀

[Pepperpot22 in reply to Boxerlady]

Thank u I’m on 20mg methotrexate tablets so presume it’ll be the same dose for injection. Didn’t think to ask!

[Topcar]

Yes I found metoject got right to the point reducing inflammation and pain and also stopped my GI issues and slowed down my hair loss which were side effects of the pills ! I was a little skeptical when my rheumy changed it but he was right! So fingers crossed it works for you 🤞

[Pepperpot22 in reply to Topcar]

Thank u. Luvly to hear that it can make a difference!

[Mmrr]

MTX injections made no difference to me at all, the side effects remained, exactly as when I took MTX tablets. But worth trying as some people do see a reduction in side effects 🤞

[Pepperpot22 in reply to Mmrr]

Luckily I get no side effects from methotrexate. Wud luv a reduction in pain levels 🤞

[Madmusiclover in reply to Mmrr]

Same for me.

[stbernhard]

Hi Pepperpot, the injections reduced the nausea greatly and it's so much nicer than having to take tablets. Go with it! All the best.

[Pepperpot22 in reply to stbernhard]

Thank u!

[stbernhard]

Hi Pepperpot, the injections reduced the nausea greatly and it's so much nicer than having to take tablets. Go with it! All the best.

[Pepperpot22 in reply to stbernhard]

Thank u!

[Gnarli]

The injections certainly helped me. As others have already said, the med bypasses the GI tract so more of the med is accessible to you. Let's hope you get the same effects as I have enjoyed.

[Pepperpot22 in reply to Gnarli]

Really keeping my fingers crossed!

[RootsToots]

Mtx just didn't work for me. Though metrojet pens did reduce the sickness quite a bit.

[Pepperpot22 in reply to RootsToots]

Seems like it doesn’t work for everyone. Get no side effects from the tablets, just hoping for less pain

[GillB45]

Hi. Injection’s definitely give me less side effects.

I would recommend these instead of tablet form.

Try and pace yourself too that always helps.

I find the side effects are worse when I’m exhausted.

Ginger water helps me too, it helps with the nausea from methotrexate

If you need any more advice please let me know I happy to help.

[Pepperpot22 in reply to GillB45]

Thank u!

[Nana-8]

I too went from 20 mg pill to injection of 2. MTX. I was content but still had flares. When the dose was upped fo 2.5 I started experiencing migraines. Rather than backing it back down and adding low dose prednisone again - they switched me to 20 mg. Leflunomide pill. The only side effect with this med is still hair loss ( folic acid eliminated ) and skin rash like invisible leather on my face neck and back. I have to use creams daily to help.

[Maggiemae58]

so hard on your system. At first (1 yr) it helped but on maximum now (25 mgm) and having flare ups constantly now. RA Dr wants to add Thalidomide????

[Pepperpot22 in reply to Maggiemae58]

I hope something works for u 🤞