Update - Had to stop Leflunomide

[Haz58]

12 days I've had diarrhea now. Lost 8lb in weight (great but not this way). Done a stool test, one for some bacterial thing is negative, waiting on the rest. GP and Rheumy nurse are pretty sure it's from the Leflunomide I took for only 2 weeks and 5 days. Phone appointment with RA consultant is Wednesday morning not a f 2 f as I thought but good job really. Be interesting to see what she says! I wonder how long this tummy problem will go on...

Well it happened...2 weeks of 10mg of Leflunomide and nurse rang and said my inflammatory marker was up. Take 20mg she said. So for 2 days I did. Yep I got terrible upset tum with diarrhea. Rang nurse on friday she said stop taking it and because of past problems I shouldn't have been told to double the dose 🙄 I was itching a over too. Ive had diarrhea now for a week. Has anyone else had this and how long did the diarrhea last after stopping the Leflunomide?

She also got me an urgent appointment with my consultant and I go next Wednesday.

[KittyJ]

I think lef has a long half life so that may be why you still have diarrhoea, hopefully your consultant will be able to help you when you see him if you haven’t improved by then. Make sure you keep hydrated ( though I’m sore you know this 😊)

[smilelines]

I had to change to 10 mg two times a day. Once in the morning and one at dinner.

[Artemise]

Yes, I had this problem back in 2018 and it should hopefully pass soon you've stopped taking the drug. Wishing you well.