Hydroxychloroquine and Sulfasalazine combo - NRAS

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Hydroxychloroquine and Sulfasalazine combo

gr95 profile image
gr95
21 Replies

Hi all,

Just been added Sulfasalazine to my medication alongside Hydroxychloroquine. Anyone have any experience of these in combination?

Thanks!

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gr95
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21 Replies
Boxerlady profile image
Boxerlady

I had Sulphasalzine added to my existing Methotrexate and Hydroxychloroquin and the combination has been great for me. I had some slight nausea initially but it passed after a few days and the only long-term side effect is the dramatic yellow wee 😂 My longstanding IBS-C seems to have settled down though 😉

gr95 profile image
gr95 in reply toBoxerlady

Top stuff thanks for the insight!

allanah profile image
allanah

Yes I had them I did get my eyes checked yearly but didn't have any problems and I think if I remember I had slightly orange wee but no infections or anything. I remember it really reduced my swelling a lot and helped the pain.

Eventually I ended up on biologic but that combination worked for a good while as I couldn't tolerate methotrexate. Good luck, fingers crossed this sorts you right out xxx

gr95 profile image
gr95 in reply toallanah

Same here regarding MTX, thanks for the insight!

allanah profile image
allanah in reply togr95

Good luck

sylvi profile image
sylvi in reply toallanah

I too can't have MTX due to having a ground glass appearance on my lungs, and with biologicals i get too many ifections to take them again.xxx

MaryEmma2 profile image
MaryEmma2 in reply toallanah

Why did u have your eyes checked.

gr95 profile image
gr95 in reply toMaryEmma2

Hydroxychloroquine can affect a particular part of your eye with prolonged use I believe so best to have a eye health check yearly.

allanah profile image
allanah in reply toMaryEmma2

As gr95 says. Sorry I missed your question !

zen4 profile image
zen4

I had that combination for a while and it was ok until I had my eyes checked. Hydrochloroquine is thought to sometimes causes problems to the retina but all meds have side effects so just get your eyes checked regularly. Sulphazalazine is amed I have had for donkeys years and for me there has never been any problems apart from yellow wee! I think the effects reduce after time though.

gr95 profile image
gr95 in reply tozen4

Hi Zen, yep I regularly have eye checks with Hydroxy as been on it for nearly two years now. Thanks for the comment!

sylvi profile image
sylvi

I am on that combination at the moment with no ill effects. xxxx

Llanberisman profile image
Llanberisman

I take the triple therapy…works really well to keep the RA in remission and no apparent side effects.

gr95 profile image
gr95 in reply toLlanberisman

What’s the triple therapy?

Boxerlady profile image
Boxerlady in reply togr95

I'm on triple therapy - Methotrexate, Hydroxychloroquin and Sulphasalzine

Llanberisman profile image
Llanberisman in reply togr95

As said by Boxerlady…

Ferret18 profile image
Ferret18

Hi gr95I had that combo (then had Leflunomide added after difficulties with methotrexate). No severe side effects, just yellow wee and it can colour my teeth too, so I always clean my teeth after taking it.

Good luck

Scottishlad profile image
Scottishlad

In addition to the coloured pee, it can also colour your sweat and light coloured clothing can be affected.

This combination worked for me for a few years before Methotrexate was added. I'm now on Methotrexate, Hydrochloroquine and Cimzia biologic.

Biofreak profile image
Biofreak

Hi. I couldn't tolerate methotrexate so was put on sulphasalazine. Been on it for years with no noticeable side effects apart from yellow wee. It was very effective at first but the effectiveness began to wear off so leflunomide was added but I started losing my hair so that was stopped. Hydrochloroquine was considered but rejected because of existing eye problems. Then put on a biologic but still take sulphasalazine as well.

Green230461 profile image
Green230461

Sulfasalazine has made all the difference for me but my teeth have gone slightly yellow over the years with it. ⭐️Good luck.

bienassis profile image
bienassis

I can only comment on the Hydroxychloroquin. My rheumy wanted me to add this drug to the methotrexate some years ago after a series of flares.

I did a bit of research and found it wasn't advisable for anyone over 65 (at the time I was 75), especially if the patient had any eye trouble. My eyes were fine although by then I had had cataract surgery on both eyes. I mentioned this to my rheumy and was told "You will be OK for a while".

I thought about it and decided against. I am now 86 and wonder if it was the right decision, but there is no way of knowing. In any case I was eventually prescribed a biologic in combination with methotrexate.

It was the "for a while" that worried me. Anyone classed as elderly may find the risk unacceptable. It's not an easy choice. But at any age regular check-ups would be necessary.

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